The dental plaque biofilm matrix

NS Jakubovics, SD Goodman… - Periodontology …, 2021 - Wiley Online Library
The extracellular matrix is a critical component of microbial biofilms, such as dental plaque,
maintaining the spatial arrangement of cells and coordinating cellular functions throughout …

Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line

KY How, KP Song, KG Chan - Frontiers in microbiology, 2016 - frontiersin.org
Periodontal disease represents a group of oral inflammatory infections initiated by oral
pathogens which exist as a complex biofilms on the tooth surface and cause destruction to …

DNABII proteins play a central role in UPEC biofilm structure

A Devaraj, SS Justice, LO Bakaletz… - Molecular …, 2015 - Wiley Online Library
Most chronic and recurrent bacterial infections involve a biofilm component, the foundation
of which is the extracellular polymeric substance (EPS). Extracellular DNA (e DNA) is a …

Natural antigenic differences in the functionally equivalent extracellular DNABII proteins of bacterial biofilms provide a means for targeted biofilm therapeutics

CJ Rocco, ME Davey, LO Bakaletz… - Molecular oral …, 2017 - Wiley Online Library
Bacteria that persist in the oral cavity exist within complex biofilm communities. A hallmark of
biofilms is the presence of an extracellular polymeric substance (EPS), which consists of …

Effects of the histone-like protein HU on cellulose degradation and biofilm formation of Cytophaga hutchinsonii

Z Guan, Y Wang, L Gao, W Zhang, X Lu - Applied Microbiology and …, 2018 - Springer
Cytophaga hutchinsonii, belonging to Bacteroidetes, is speculated to use a novel cell-
contact mode to digest cellulose. In this study, we identified a histone-like protein HU …

A Novel Regulation of K-antigen Capsule Synthesis in Porphyromonas gingivalis Is Driven by the Response Regulator PG0720-Directed Antisense RNA

HM Kim, DK Ranjit, AR Walker, H Getachew… - Frontiers in Oral …, 2021 - frontiersin.org
The periodontal pathogen Porphyromonas gingivalis strain W83 displays at least three
different surface glycans, specifically two types of lipopolysaccharides (O-LPS and A-LPS) …

Deletion of a 77-base-pair inverted repeat element alters the synthesis of surface polysaccharides in Porphyromonas gingivalis

BW Bainbridge, T Hirano, N Grieshaber… - Journal of …, 2015 - journals.asm.org
Bacterial cell surface glycans, such as capsular polysaccharides and lipopolysaccharides
(LPS), influence host recognition and are considered key virulence determinants. The …

HU specific interfering agents

LO Bakaletz, SD Goodman - US Patent 11,690,892, 2023 - Google Patents
2018-10-29 Assigned to RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S
HOSPITAL reassignment RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S …

Formulation for the elimination of cariogenic and opportunistic pathogens within the oral cavity

SD Goodman, LM Warren - US Patent 11,484,479, 2022 - Google Patents
US11484479B2 - Formulation for the elimination of cariogenic and opportunistic pathogens
within the oral cavity - Google Patents US11484479B2 - Formulation for the elimination of …

Compositions and methods for mediating eps

SD Goodman, LO Bakaletz - US Patent App. 17/256,640, 2021 - Google Patents
2020-12-28 Assigned to RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S
HOSPITAL reassignment RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S …