[HTML][HTML] Making neurons, made easy: The use of Neurogenin-2 in neuronal differentiation
Directed neuronal differentiation of human pluripotent stem cells (hPSCs), neural
progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly …
progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly …
Opportunities and limitations for studying neuropsychiatric disorders using patient-derived induced pluripotent stem cells
Neuropsychiatric disorders affect a large proportion of the global population and there is an
urgent need to understand the pathogenesis and to develop novel and improved treatments …
urgent need to understand the pathogenesis and to develop novel and improved treatments …
Modeling gene× environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression
Post-traumatic stress disorder (PTSD) can develop following severe trauma, but the extent to
which genetic and environmental risk factors contribute to individual clinical outcomes is …
which genetic and environmental risk factors contribute to individual clinical outcomes is …
[HTML][HTML] Map** cis-regulatory elements in human neurons links psychiatric disease heritability and activity-regulated transcriptional programs
Genome-wide association studies (GWASs) have identified hundreds of loci associated with
psychiatric diseases, yet there is a lack of understanding of disease pathophysiology …
psychiatric diseases, yet there is a lack of understanding of disease pathophysiology …
The autism–psychosis continuum conundrum: exploring the role of the endocannabinoid system
Evidence indicates shared physiopathological mechanisms between autism and psychosis.
In this regard, the endocannabinoid system has been suggested to modulate neural circuits …
In this regard, the endocannabinoid system has been suggested to modulate neural circuits …
Stem cell models for context-specific modeling in psychiatric disorders
Genome-wide association studies reveal the complex polygenic architecture underlying
psychiatric disorder risk, but there is an unmet need to validate causal variants, resolve their …
psychiatric disorder risk, but there is an unmet need to validate causal variants, resolve their …
[HTML][HTML] Probing the molecular and cellular pathological mechanisms of schizophrenia using human induced pluripotent stem cell models
With recent advancements in psychiatric genomics, as a field,“stem cell-based disease
modelers” were given the exciting yet daunting task of translating the extensive list of …
modelers” were given the exciting yet daunting task of translating the extensive list of …
Cannabis use in autism: reasons for concern about risk for psychosis
Being particularly vulnerable to the pro-psychotic effects of cannabinoid exposure, autism
spectrum individuals present with an increased risk of psychosis, which may be passed on …
spectrum individuals present with an increased risk of psychosis, which may be passed on …
Rapid conversion of human induced pluripotent stem cells into dopaminergic neurons by inducible expression of two transcription factors
K Nishimura, T Nitta, K Doi, K Takata - Stem Cells and Development, 2022 - liebertpub.com
Human pluripotent stem cells (hPSCs), including human embryonic stem cells and human
induced pluripotent stem cells (hiPSCs), provide promising sources for regenerative therapy …
induced pluripotent stem cells (hiPSCs), provide promising sources for regenerative therapy …
3D genome plasticity in normal and diseased neurodevelopment
A Plaza-Jennings, A Valada, S Akbarian - Genes, 2022 - mdpi.com
Non-random spatial organization of the chromosomal material inside the nuclei of brain cells
emerges as an important regulatory layer of genome organization and function in health and …
emerges as an important regulatory layer of genome organization and function in health and …