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Structural Immunology of SARS‐CoV‐2
M Yuan, IA Wilson - Immunological Reviews, 2025 - Wiley Online Library
ABSTRACT The SARS‐CoV‐2 spike (S) protein has undergone significant evolution,
enhancing both receptor binding and immune evasion. In this review, we summarize …
enhancing both receptor binding and immune evasion. In this review, we summarize …
Omicron-specific ultra-potent SARS-CoV-2 neutralizing antibodies targeting the N1/N2 loop of Spike N-terminal domain
ABSTRACT A multitude of functional mutations continue to emerge on the N-terminal
domain (NTD) of the spike protein in SARS-CoV-2 Omicron subvariants. Understanding the …
domain (NTD) of the spike protein in SARS-CoV-2 Omicron subvariants. Understanding the …
A broadly neutralizing antibody against the SARS-CoV-2 Omicron sub-variants BA. 1, BA. 2, BA. 2.12. 1, BA. 4, and BA. 5
Z Chen, L Feng, L Wang, L Zhang, B Zheng… - … and Targeted Therapy, 2025 - nature.com
The global spread of Severe Acute Respiratory Syndrome Coronavirus 2.(SARS-CoV-2) and
its variant strains, including Alpha, Beta, Gamma, Delta, and now Omicron, pose a significant …
its variant strains, including Alpha, Beta, Gamma, Delta, and now Omicron, pose a significant …
A potent, broadly neutralizing human monoclonal antibody that efficiently protects hACE2-transgenic mice from infection with the Wuhan, BA. 5, and XBB. 1.5 SARS …
The COVID-19 pandemic has uncovered the high genetic variability of the SARS-CoV-2
virus and its ability to evade the immune responses that were induced by earlier viral …
virus and its ability to evade the immune responses that were induced by earlier viral …
[HTML][HTML] Mutational Scanning and Binding Free Energy Computations of the SARS-CoV-2 Spike Complexes with Distinct Groups of Neutralizing Antibodies: Energetic …
M Alshahrani, V Parikh, B Foley, N Raisinghani… - International Journal of …, 2025 - mdpi.com
The rapid evolution of SARS-CoV-2 has led to the emergence of variants with increased
immune evasion capabilities, posing significant challenges to antibody-based therapeutics …
immune evasion capabilities, posing significant challenges to antibody-based therapeutics …
[HTML][HTML] Quantitative Characterization and Prediction of the Binding Determinants and Immune Escape Hotspots for Groups of Broadly Neutralizing Antibodies Against …
M Alshahrani, V Parikh, B Foley, N Raisinghani… - Biomolecules, 2025 - mdpi.com
A growing body of experimental and computational studies suggests that the cross-
neutralization antibody activity against Omicron variants may be driven by the balance and …
neutralization antibody activity against Omicron variants may be driven by the balance and …
Optimizing a Human Monoclonal Antibody for Better Neutralization of SARS-CoV-2
SUMMARY SARS-CoV-2 has largely evolved to resist antibody pressure, with each
successive viral variant becoming more and more resistant to serum antibodies in the …
successive viral variant becoming more and more resistant to serum antibodies in the …