In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

After more than a century from its discovery, valproic acid (VPA) still represents one of the
most efficient antiepileptic drugs (AEDs). Pre and post-synaptic effects of VPA depend on a …

Personalized biomedical devices have enormous potential to solve clinical challenges in
urgent medical situations. Despite this potential, a device for in situ treatment of fatal …

Epilepsy is a chronic neurological condition characterized by recurrent seizures that affects
millions of people worldwide. Comprehension of the complex mechanisms underlying …

The most common forms of acquired epilepsies arise following acute brain insults such as
traumatic brain injury, stroke, or central nervous system infections. Treatment is effective for …

Pentylenetetrazole (PTZ) is a GABA-A receptor antagonist. An intraperitoneal injection of
PTZ into an animal induces an acute, severe seizure at a high dose, whereas sequential …

Animal models for seizures and epilepsy have played a fundamental role in advancing our
understanding of basic mechanisms underlying ictogenesis and epileptogenesis and have …

Despite the development of various new antiepileptic drugs (AEDs) since the early 1990s,
the available evidence indicates that the efficacy and tolerability of drug treatment of …

Understanding the pathophysiogenesis of temporal lobe epilepsy (TLE) largely rests on the
use of models of status epilepticus (SE), as in the case of the pilocarpine model. The main …

Antiepileptic drugs (AEDs) provide satisfactory control of seizures for most patients with
epilepsy. The drugs have the remarkable ability to protect against seizures while permitting …