Abstract The PI3 K/AKT/mTOR signalling pathway plays an important role in the regulation of
signal transduction and biological processes such as cell proliferation, apoptosis …

The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of
rapamycin (mTOR) pathway is one of the most important intracellular pathways involved in …

Polycystic ovary syndrome (PCOS) is a disease in which endocrine metabolic abnormalities
coexist with reproductive system abnormalities, with the main clinical manifestations …

Myocardial ischemia has a high incidence and mortality rate, and reperfusion is currently the
standard intervention. However, reperfusion may lead to further myocardial damage, known …

The leading cause of death in developed countries is cardiovascular disease, where
coronary heart disease is the main cause of death. Myocardial reperfusion is the most …

Abstract O-linked-N-acetylglucosaminylation (O-GlcNAcylation), a dynamic post-
translational modification (PTM), holds profound implications in controlling various cellular …

The complex pathophysiological mechanisms behind destructive chronic conditions,
including cancer, neurodegenerative diseases, diabetes mellitus, cardiovascular diseases …

The development of the foetal heart is driven by increased glucose uptake and activation of
mammalian target of rapamycin (mTOR) and hypoxia‐inducible factor‐1α (HIF‐1α), which …

Tissue injury causes activation of mesenchymal lineage cells into wound-repairing
myofibroblasts (MFs), whose uncontrolled activity ultimately leads to fibrosis. Although this …

With lifestyle changes, chronic diseases have become a public health problem worldwide,
causing a huge burden on the global economy. Risk factors associated with chronic …