The BLAST programs are widely used tools for searching protein and DNA databases for
sequence similarities. For protein comparisons, a variety of definitional, algorithmic and …

Protein phosphorylation plays a cardinal role in regulating many cellular processes in
eukaryotes. In particular, protein phosphorylation is a major currency of signal transduction …

The human genome holds an extraordinary trove of information about human development,
physiology, medicine and evolution. Here we report the results of an international …

The eukaryotic protein kinases make up a large superfamily of homologous proteins. They
are related by virtue of their kinase domains (also known as catalytic domains), which …

Widmann, Christian, Spencer Gibson, Matthew B. Jarpe, and Gary L. Johnson. Mitogen-
Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human …

Meiotic recombination in S. cerevisiae is initiated by double-strand breaks (DSBs). In certain
mutants, breaks accumulate with a covalently attached protein, suggesting that cleavage is …

ENDOGENOUS neuromodulatory molecules are commonly coupled to specific metabolic
enzymes to ensure rapid signal inactivation. Thus, acetylcholine is hydrolysed by …

Von Willebrand factor (VWF) is a blood glycoprotein that is required for normal hemostasis,
and deficiency of VWF, or von Willebrand disease (VWD), is the most common inherited …

The complete nucleotide sequence (580,070 base pairs) of the Mycoplasma genitalium
genome, the smallest known genome of any free-living organism, has been determined by …

Replication protein A [RPA; also known as replication factor A (RFA) and human single-
stranded DNA-binding protein] is a single-stranded DNA-binding protein that is required for …