Small RNAs, large networks: posttranscriptional regulons in gram-negative bacteria
Small regulatory RNA (sRNAs) are key mediators of posttranscriptional gene control in
bacteria. Assisted by RNA-binding proteins, a single sRNA often modulates the expression …
bacteria. Assisted by RNA-binding proteins, a single sRNA often modulates the expression …
Bacterial RNA chaperones and chaperone-like riboregulators: behind the scenes of RNA-mediated regulation of cellular metabolism
In all domains of life, RNA chaperones safeguard and guide the fate of the cellular RNA
pool. RNA chaperones comprise structurally diverse proteins that ensure proper folding …
pool. RNA chaperones comprise structurally diverse proteins that ensure proper folding …
Dynamic refolding of OxyS sRNA by the Hfq RNA chaperone
Abstract The Sm protein Hfq chaperones small non-coding RNAs (sRNAs) in bacteria,
facilitating sRNA regulation of target mRNAs. Hfq acts in part by remodeling the sRNA and …
facilitating sRNA regulation of target mRNAs. Hfq acts in part by remodeling the sRNA and …
Target recognition by RNase E RNA-binding domain AR2 drives sRNA decay in the absence of PNPase
The C-terminal domain (CTD) of the major endoribonuclease RNase E not only serves as a
scaffold for the central RNA decay machinery in gram-negative bacteria but also mediates …
scaffold for the central RNA decay machinery in gram-negative bacteria but also mediates …
Unraveling membrane perturbations caused by the bacterial riboregulator Hfq
F Turbant, J Waeytens, C Campidelli… - International Journal of …, 2022 - mdpi.com
Hfq is a pleiotropic regulator that mediates several aspects of bacterial RNA metabolism.
The protein notably regulates translation efficiency and RNA decay in Gram-negative …
The protein notably regulates translation efficiency and RNA decay in Gram-negative …
Glutamine synthetase mRNA releases sRNA from its 3′ UTR to regulate carbon/nitrogen metabolic balance in Enterobacteriaceae
M Miyakoshi, T Morita, A Kobayashi, A Berger… - Elife, 2022 - elifesciences.org
Glutamine synthetase (GS) is the key enzyme of nitrogen assimilation induced under
nitrogen limiting conditions. The carbon skeleton of glutamate and glutamine, 2 …
nitrogen limiting conditions. The carbon skeleton of glutamate and glutamine, 2 …
TRS: a method for determining transcript termini from RNAtag-seq sequencing data
A Bar, L Argaman, M Eldar, H Margalit - Nature Communications, 2023 - nature.com
In bacteria, determination of the 3'termini of transcripts plays an essential role in regulation
of gene expression, affecting the functionality and stability of the transcript. Several …
of gene expression, affecting the functionality and stability of the transcript. Several …
An acetyltransferase moonlights as a regulator of the RNA binding repertoire of the RNA chaperone Hfq in Escherichia coli
Bacterial small RNAs (sRNAs) regulate gene expression by base-pairing with their target
mRNAs. In Escherichia coli and many other bacteria, this process is dependent on the RNA …
mRNAs. In Escherichia coli and many other bacteria, this process is dependent on the RNA …
Intrinsically disordered interaction network in an RNA chaperone revealed by native mass spectrometry
RNA-binding proteins contain intrinsically disordered regions whose functions in RNA
recognition are poorly understood. The RNA chaperone Hfq is a homohexamer that contains …
recognition are poorly understood. The RNA chaperone Hfq is a homohexamer that contains …
Transcriptome-scale analysis uncovers conserved residues in the hydrophobic core of the bacterial RNA chaperone Hfq required for small regulatory RNA stability
J McQuail, M Krepl, K Katsuya-Gaviria… - Nucleic Acids …, 2025 - academic.oup.com
The RNA chaperone Hfq plays crucial roles in bacterial gene expression and is a major
facilitator of small regulatory RNA (sRNA) action. The toroidal architecture of the Hfq …
facilitator of small regulatory RNA (sRNA) action. The toroidal architecture of the Hfq …