Tertiary lymphoid structures (TLSs) are ectopic lymphoid organs that develop in non-
lymphoid tissues at sites of chronic inflammation including tumours. Key common …

Recent data show that B cells and plasma cells located in tumours or in tumour-draining
lymph nodes can have important roles in sha** antitumour immune responses. In tumour …

The presence of intratumoral tertiary lymphoid structures (TLS) is associated with positive
clinical outcomes and responses to immunotherapy in cancer. Here, we used spatial …

The consensus molecular subtype (CMS) classification of colorectal cancer is based on bulk
transcriptomics. The underlying epithelial cell diversity remains unclear. We analyzed …

Immunotherapy for metastatic colorectal cancer is effective only for mismatch repair-deficient
tumors with high microsatellite instability that demonstrate immune infiltration, suggesting …

Although patients with microsatellite instable metastatic colorectal cancer (CRC) benefit from
immune checkpoint blockade, chemotherapy with targeted therapies remains the only …

Immunotherapy has revolutionized colon cancer treatment. Immune checkpoint inhibitors
(ICIs) have shown clinical benefits for colon cancer patients, especially those with high …

Background For virtually every patient with colorectal cancer (CRC), hematoxylin–eosin
(HE)–stained tissue slides are available. These images contain quantitative information …

Hel** B cells and antibody responses is a major function of CD4+ T cells. It has been 10
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …

The clinical successes in immunotherapy have been both astounding and at the same time
unsatisfactory. Countless patients with varied tumor types have seen pronounced clinical …