Antiviral peptides as anti-influenza agents

M Agamennone, M Fantacuzzi, G Vivenzio… - International Journal of …, 2022 - mdpi.com
Influenza viruses represent a leading cause of high morbidity and mortality worldwide.
Approaches for fighting flu are seasonal vaccines and some antiviral drugs. The …

From exploring cancer and virus targets to discovering active peptides through mRNA display

J Brango-Vanegas, ML Leite, KBS de Oliveira… - Pharmacology & …, 2023 - Elsevier
During carcinogenesis, neoplastic cells accumulate mutations in genes important for cellular
homeostasis, producing defective proteins. Viral infections occur when viral capsid proteins …

[HTML][HTML] Deciphering the intrinsic dynamics of unphosphorylated IRAK4 kinase bound to type I and type II inhibitors

V Gosu, S Sasidharan, P Saudagar… - Computers in Biology …, 2023 - Elsevier
Abstract Interleukin-1 receptor-associated kinase 4 (IRAK4) is a vital protein involved in Toll-
like and interleukin-1 receptor signal transduction. Several studies have reported regarding …

Molecular dynamics of the ERRγ ligand-binding domain bound with agonist and inverse agonist

S Sasidharan, K Radhakrishnan, JY Lee, P Saudagar… - Plos one, 2023 - journals.plos.org
Estrogen-related receptor gamma (ERRγ), the latest member of the ERR family, does not
have any known reported natural ligands. Although the crystal structures of the apo, agonist …