Microglia in Alzheimer disease: well-known targets and new opportunities

AL Hemonnot, J Hua, L Ulmann… - Frontiers in aging …, 2019 - frontiersin.org
Microglia are the resident macrophages of the central nervous system. They play key roles
in brain development, and physiology during life and aging. Equipped with a variety of …

Revolutionizing disease modeling: the emergence of organoids in cellular systems

R Silva-Pedrosa, AJ Salgado, PE Ferreira - Cells, 2023 - mdpi.com
Cellular models have created opportunities to explore the characteristics of human diseases
through well-established protocols, while avoiding the ethical restrictions associated with …

Human iPSC-derived neural models for studying Alzheimer's disease: from neural stem cells to cerebral organoids

M Barak, V Fedorova, V Pospisilova, J Raska… - Stem Cell Reviews and …, 2022 - Springer
During the past two decades, induced pluripotent stem cells (iPSCs) have been widely used
to study mechanisms of human neural development, disease modeling, and drug discovery …

The triad of nanotechnology, cell signalling, and scaffold implantation for the successful repair of damaged organs: An overview on soft-tissue engineering

P Abdollahiyan, F Oroojalian… - Journal of controlled …, 2021 - Elsevier
As a milestone in therapeutic fields, tissue engineering has offered an alternative strategy to
address unmet clinical needs for the repair and replacement of human damaged organs …

3D bioprinting pluripotent stem cell derived neural tissues using a novel fibrin bioink containing drug releasing microspheres

R Sharma, IPM Smits, L De La Vega, C Lee… - … in bioengineering and …, 2020 - frontiersin.org
3D bioprinting combines cells with a supportive bioink to fabricate multiscale, multi-cellular
structures that imitate native tissues. Here, we demonstrate how our novel fibrin-based …

3D printed conductive nanocellulose scaffolds for the differentiation of human neuroblastoma cells

M Bordoni, E Karabulut, V Kuzmenko, V Fantini… - Cells, 2020 - mdpi.com
We prepared cellulose nanofibrils-based (CNF), alginate-based and single-walled carbon
nanotubes (SWCNT)-based inks for freeform reversible embedding hydrogel (FRESH) 3D …

Neuroinflammatory In Vitro Cell Culture Models and the Potential Applications for Neurological Disorders

Y Peng, S Chu, Y Yang, Z Zhang, Z Pang… - Frontiers in …, 2021 - frontiersin.org
Cell cultures are used in pharmaceutical, medical and biological sciences. Due to the ethical
and cost limitations of in vivo models, the replaceable cell model that is more closely related …

Advances in current in vitro models on neurodegenerative diseases

I Pereira, MJ Lopez-Martinez, J Samitier - Frontiers in Bioengineering …, 2023 - frontiersin.org
Many neurodegenerative diseases are identified but their causes and cure are far from
being well-known. The problem resides in the complexity of the neural tissue and its location …

Retinal ganglion cells with a glaucoma OPTN (E50K) mutation exhibit neurodegenerative phenotypes when derived from three-dimensional retinal organoids

KB VanderWall, KC Huang, Y Pan, SS Lavekar… - Stem Cell Reports, 2020 - cell.com
Retinal ganglion cells (RGCs) serve as the connection between the eye and the brain, with
this connection disrupted in glaucoma. Numerous cellular mechanisms have been …

[PDF][PDF] Chromium VI: A Silent Aggressor in Sickle Cell Anemia Pathophysiology

EI Obeagu - Elite Journal of Haematology, 2024 - academia.edu
Abstract Sickle Cell Anemia (SCA), a hereditary hemoglobinopathy, is characterized by
distorted red blood cells leading to vaso-occlusive complications and chronic hemolytic …