Early life stress and development: potential mechanisms for adverse outcomes
Background Chronic and/or extreme stress in early life, often referred to as early adversity,
childhood trauma, or early life stress, has been associated with a wide range of adverse …
childhood trauma, or early life stress, has been associated with a wide range of adverse …
Animal models of major depression: drawbacks and challenges
Major depression is a leading contributor to the global burden of disease. This situation is
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …
Adult hippocampal neurogenesis buffers stress responses and depressive behaviour
JS Snyder, A Soumier, M Brewer, J Pickel… - Nature, 2011 - nature.com
Glucocorticoids are released in response to stressful experiences and serve many beneficial
homeostatic functions. However, dysregulation of glucocorticoids is associated with …
homeostatic functions. However, dysregulation of glucocorticoids is associated with …
The adaptive calibration model of stress responsivity
This paper presents the Adaptive Calibration Model (ACM), an evolutionary–developmental
theory of individual differences in the functioning of the stress response system. The stress …
theory of individual differences in the functioning of the stress response system. The stress …
Modulation of the hypothalamic-pituitary-adrenal axis by early life stress exposure
M Van Bodegom, JR Homberg… - Frontiers in cellular …, 2017 - frontiersin.org
Exposure to stress during critical periods in development can have severe long-term
consequences, increasing overall risk on psychopathology. One of the key stress response …
consequences, increasing overall risk on psychopathology. One of the key stress response …
Early life adversity shapes neural circuit function during sensitive postnatal developmental periods
Early life adversity (ELA) is a major risk factor for mental illness, but the neurobiological
mechanisms by which ELA increases the risk for future psychopathology are still poorly …
mechanisms by which ELA increases the risk for future psychopathology are still poorly …
Beyond risk and protective factors: An adaptation-based approach to resilience
How does repeated or chronic childhood adversity shape social and cognitive abilities?
According to the prevailing deficit model, children from high-stress backgrounds are at risk …
According to the prevailing deficit model, children from high-stress backgrounds are at risk …
Stress effects on memory: an update and integration
It is well known that stressful experiences may affect learning and memory processes. Less
clear is the exact nature of these stress effects on memory: both enhancing and impairing …
clear is the exact nature of these stress effects on memory: both enhancing and impairing …
Chronic stress followed by social isolation promotes depressive-like behaviour, alters microglial and astrocyte biology and reduces hippocampal neurogenesis in …
Unpredictable chronic mild stress (UCMS) is one of the most commonly used, robust and
translatable models for studying the neurobiological basis of major depression. Although the …
translatable models for studying the neurobiological basis of major depression. Although the …
The adverse childhood experiences questionnaire: Two decades of research on childhood trauma as a primary cause of adult mental illness, addiction, and medical …
EM Zarse, MR Neff, R Yoder, L Hulvershorn… - Cogent …, 2019 - Taylor & Francis
Abstract Objective. In 1998, Felitti and colleagues published the first study of the Adverse
Childhood Experiences-Questionnaire (ACE-Q), a 10-item scale used to correlate childhood …
Childhood Experiences-Questionnaire (ACE-Q), a 10-item scale used to correlate childhood …