Deep brain stimulation (DBS) is a neurosurgical procedure that allows targeted circuit-based
neuromodulation. DBS is a standard of care in Parkinson disease, essential tremor and …

A major challenge in Parkinson's disease is the variability in symptoms and rates of
progression, underpinned by heterogeneity of pathological processes. Biomarkers are …

Deep brain stimulation (DBS) is a neurosurgical intervention where electrodes are
permanently implanted into the brain in order to modulate pathologic neural activity. The …

Research in ultrahigh magnetic field strength combined with ultrahigh and ultrafast gradient
technology has provided enormous gains in sensitivity, resolution, and contrast for …

Deep brain stimulation (DBS) is a well-established and effective treatment for patients with
advanced Parkinson's disease (PD), yet its underlying mechanisms remain enigmatic …

In recent years, ultra-high field MRI (7 T and above) has received more interest for clinical
imaging. Indeed, a number of studies have shown the benefits from the application of this …

Apathy is commonly defined as a loss of motivation leading to a reduction in goal-directed
behaviors. This multidimensional syndrome, which includes cognitive, emotional and …

Over the last decades, extensive basic and clinical knowledge has been acquired on the
use of subthalamic nucleus (STN) deep brain stimulation (DBS) for Parkinson's disease …

The Subthalamic Nucleus (STh) is an oval-shaped diencephalic structure located ventrally
to the thalamus, playing a fundamental role in the circuitry of the basal ganglia. In addition to …

Advances in computational neuroimaging techniques have expanded the armamentarium of
imaging tools available for clinical applications in clinical neuroscience. Non-invasive, in …