Molecular evolution of antifungal drug resistance
The fungal pathogens Candida albicans, Cryptococcus neoformans, and Aspergillus
fumigatus have transitioned from a rare curiosity to a leading cause of human mortality. The …
fumigatus have transitioned from a rare curiosity to a leading cause of human mortality. The …
[HTML][HTML] Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases
Monoclonal antibodies are being developed as therapeutics to complement drugs and
vaccines or to fill the gap where no drugs or vaccines exist. These therapeutic antibodies …
vaccines or to fill the gap where no drugs or vaccines exist. These therapeutic antibodies …
The capsule of the fungal pathogen Cryptococcus neoformans
The capsule of the fungal pathogen Cryptococcus neoformans has been studied extensively
in recent decades and a large body of information is now available to the scientific …
in recent decades and a large body of information is now available to the scientific …
Infectious complications of biological and small molecule targeted immunomodulatory therapies
The past 2 decades have seen a revolution in our approach to therapeutic
immunosuppression. We have moved from relying on broadly active traditional medications …
immunosuppression. We have moved from relying on broadly active traditional medications …
RETRACTED: Immunotherapies against human bacterial and fungal infectious diseases: A review
Nations' ongoing struggles with a number of novel and reemerging infectious diseases,
including the ongoing global health issue, the SARS-Co-V2 (severe acute respiratory …
including the ongoing global health issue, the SARS-Co-V2 (severe acute respiratory …
Complement inhibition at the level of C3 or C5: mechanistic reasons for ongoing terminal pathway activity
M Mannes, A Dopler, O Zolk, SJ Lang… - Blood, The Journal …, 2021 - ashpublications.org
Blocking the terminal complement pathway with the C5 inhibitor eculizumab has
revolutionized the clinical management of several complement-mediated diseases and has …
revolutionized the clinical management of several complement-mediated diseases and has …
B cells and antibodies in the defense against Mycobacterium tuberculosis infection
JM Achkar, J Chan, A Casadevall - Immunological reviews, 2015 - Wiley Online Library
Better understanding of the immunological components and their interactions necessary to
prevent or control Mycobacterium tuberculosis (Mtb) infection in humans is critical for …
prevent or control Mycobacterium tuberculosis (Mtb) infection in humans is critical for …
Cryptococcal interactions with the host immune system
Opportunistic pathogens have become of increasing medical importance over the last
decade due to the AIDS pandemic. Not only is cryptococcosis the fourth-most-common fatal …
decade due to the AIDS pandemic. Not only is cryptococcosis the fourth-most-common fatal …
Cryptococcus interactions with macrophages: evasion and manipulation of the phagosome by a fungal pathogen
C ryptococcus is a potentially fatal fungal pathogen and a leading cause of death in
immunocompromised patients. As an opportunistic and facultative intracellular pathogen of …
immunocompromised patients. As an opportunistic and facultative intracellular pathogen of …
Immunoglobulins in defense, pathogenesis, and therapy of fungal diseases
A Casadevall, L Pirofski - Cell host & microbe, 2012 - cell.com
Only two decades ago antibodies to fungi were thought to have little or no role in protection
against fungal diseases. However, subsequent research has provided convincing evidence …
against fungal diseases. However, subsequent research has provided convincing evidence …