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The link between multiple sclerosis and depression
A Feinstein, S Magalhaes, JF Richard, B Audet… - Nature Reviews …, 2014 - nature.com
Depression—be it a formal diagnosis based on consensus clinical criteria, or a collection of
symptoms revealed by a self-report rating scale—is common in patients with multiple …
symptoms revealed by a self-report rating scale—is common in patients with multiple …
How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans
T Frodl, V O'Keane - Neurobiology of disease, 2013 - Elsevier
There is evidence that excessive stress exposure of the brain, mediated through the
neurotoxic effects of cortisol and possibly neuroinflammation, causes damage to brain …
neurotoxic effects of cortisol and possibly neuroinflammation, causes damage to brain …
The hippocampus in aging and disease: from plasticity to vulnerability
T Bartsch, P Wulff - Neuroscience, 2015 - Elsevier
The hippocampus has a pivotal role in learning and in the formation and consolidation of
memory and is critically involved in the regulation of emotion, fear, anxiety, and stress …
memory and is critically involved in the regulation of emotion, fear, anxiety, and stress …
Neuroinflammatory TNFα impairs memory via astrocyte signaling
S Habbas, M Santello, D Becker, H Stubbe, G Zappia… - Cell, 2015 - cell.com
The occurrence of cognitive disturbances upon CNS inflammation or infection has been
correlated with increased levels of the cytokine tumor necrosis factor-α (TNFα). To date …
correlated with increased levels of the cytokine tumor necrosis factor-α (TNFα). To date …
Multiple sclerosis and depression
A Feinstein - Multiple Sclerosis Journal, 2011 - journals.sagepub.com
Clinically significant depression can affect up to 50% of patients with multiple sclerosis over
the course of their lifetime. It is associated with an increased morbidity and mortality and is …
the course of their lifetime. It is associated with an increased morbidity and mortality and is …
Neuroinflammation drives anxiety and depression in relapsing-remitting multiple sclerosis
S Rossi, V Studer, C Motta, S Polidoro, J Perugini… - Neurology, 2017 - neurology.org
Objective: To explore the inflammatory processes in the pathogenesis of psychiatric
symptoms and the prognostic value of psychiatric comorbidities in multiple sclerosis (MS) …
symptoms and the prognostic value of psychiatric comorbidities in multiple sclerosis (MS) …
Complement C 1q‐C 3–associated synaptic changes in multiple sclerosis hippocampus
I Michailidou, JGP Willems, EJ Kooi… - Annals of …, 2015 - Wiley Online Library
Objective Multiple sclerosis (MS) is a demyelinating disease of the central nervous system,
leading to memory impairment in up to 65% of patients. Memory dysfunction in MS has been …
leading to memory impairment in up to 65% of patients. Memory dysfunction in MS has been …
The hippocampus in multiple sclerosis
Some of the clinical manifestations of multiple sclerosis, such as memory impairment and
depression, are, at least partly, related to involvement of the hippocampus. Pathological …
depression, are, at least partly, related to involvement of the hippocampus. Pathological …
Salivary cortisol in ambulatory assessment—some dos, some don'ts, and some open questions
BM Kudielka, A Gierens, DH Hellhammer… - Biopsychosocial …, 2012 - journals.lww.com
The impact of stress on health and disease is an important research topic in psychosomatic
medicine. Because research on hypothalamic-pituitary-adrenal (HPA) axis regulation under …
medicine. Because research on hypothalamic-pituitary-adrenal (HPA) axis regulation under …
Neuropsychiatric syndromes of multiple sclerosis
R Murphy, S O'Donoghue, T Counihan… - Journal of Neurology …, 2017 - jnnp.bmj.com
Neuropsychiatric signs and symptoms occur frequently in individuals with multiple sclerosis
(MS), either as the initial presenting complaint prior to a definitive neurological diagnosis or …
(MS), either as the initial presenting complaint prior to a definitive neurological diagnosis or …