Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …

In vitro stem cell models that replicate human gastrulation have been generated, but they
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …

The female germ line undergoes a unique sequence of differentiation processes that confers
totipotency to the egg,. The reconstitution of these events in vitro using pluripotent stem cells …

Trisomic and monosomic (aneuploid) embryos account for at least 10% of human
pregnancies and, for women nearing the end of their reproductive lifespan, the incidence …

Reconstitution of female germ cell development in vitro is a key challenge in reproductive
biology and medicine. We show here that female (XX) embryonic stem cells and induced …

Germline stem cells that produce oocytes in vitro and fertilization-competent eggs in vivo
have been identified in and isolated from adult mouse ovaries. Here we describe and …

Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

The discovery of mouse embryonic stem (ES) cells> 20 years ago represented a major
advance in biology and experimental medicine, as it enabled the routine manipulation of the …

Meiosis is an essential stage in gamete formation in all sexually reproducing organisms.
Studies of mutations in model organisms and of human haplotype patterns are leading to a …