Immunotherapies for hepatocellular carcinoma
Liver cancer, more specifically hepatocellular carcinoma (HCC), is the second leading
cause of cancer-related death and its incidence is increasing globally. Around 50% of …
cause of cancer-related death and its incidence is increasing globally. Around 50% of …
[HTML][HTML] Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma
Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead
to cirrhosis, cancer, and liver failure. Liver cancer is the third leading cause of cancer …
to cirrhosis, cancer, and liver failure. Liver cancer is the third leading cause of cancer …
From bench to bed: the tumor immune microenvironment and current immunotherapeutic strategies for hepatocellular carcinoma
Y Fu, S Liu, S Zeng, H Shen - Journal of Experimental & Clinical Cancer …, 2019 - Springer
Hepatocellular carcinoma (HCC) ranks the most common primary liver malignancy and the
third leading cause of tumor-related mortality worldwide. Unfortunately, despite advances in …
third leading cause of tumor-related mortality worldwide. Unfortunately, despite advances in …
Tumor immune microenvironment and immunosuppressive therapy in hepatocellular carcinoma: a review
K Oura, A Morishita, J Tani, T Masaki - International journal of molecular …, 2021 - mdpi.com
Liver cancer has the fourth highest mortality rate of all cancers worldwide, with
hepatocellular carcinoma (HCC) being the most prevalent subtype. Despite great advances …
hepatocellular carcinoma (HCC) being the most prevalent subtype. Despite great advances …
Friend or foe? The elusive role of hepatic stellate cells in liver cancer
Liver fibrosis is a substantial risk factor for the development and progression of liver cancer,
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …
Hepatitis B virus-associated hepatocellular carcinoma
Hepatitis B virus (HBV) is DNA-based virus, member of the Hepadnaviridae family, which
can cause liver disease and increased risk of hepatocellular carcinoma (HCC) in infected …
can cause liver disease and increased risk of hepatocellular carcinoma (HCC) in infected …
Tissue CD14+CD8+ T cells reprogrammed by myeloid cells and modulated by LPS
The liver is bathed in bacterial products, including lipopolysaccharide transported from the
intestinal portal vasculature, but maintains a state of tolerance that is exploited by persistent …
intestinal portal vasculature, but maintains a state of tolerance that is exploited by persistent …
[HTML][HTML] Non-terminally exhausted tumor-resident memory HBV-specific T cell responses correlate with relapse-free survival in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) often develops following chronic hepatitis B virus (HBV)
infection and responds poorly to immune checkpoint blockade. Here, we examined the …
infection and responds poorly to immune checkpoint blockade. Here, we examined the …
Engineered T cell therapy for viral and non-viral epithelial cancers
SM Norberg, CS Hinrichs - Cancer Cell, 2023 - cell.com
Engineered T cell therapy has shown remarkable efficacy in hematologic malignancies and
has the potential for application to common epithelial cancers. Diverse T cell therapy …
has the potential for application to common epithelial cancers. Diverse T cell therapy …
Targeting human Acyl-CoA: cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint
Determining divergent metabolic requirements of T cells, and the viruses and tumours they
fail to combat, could provide new therapeutic checkpoints. Inhibition of acyl-CoA: cholesterol …
fail to combat, could provide new therapeutic checkpoints. Inhibition of acyl-CoA: cholesterol …