Microglia and monocytes/macrophages polarization reveal novel therapeutic mechanism against stroke

M Kanazawa, I Ninomiya, M Hatakeyama… - International journal of …, 2017 - mdpi.com
Stroke is a leading cause of morbidity and mortality worldwide, and consists of two types,
ischemic and hemorrhagic. Currently, there is no effective treatment to increase the survival …

Novel stroke therapeutics: unraveling stroke pathophysiology and its impact on clinical treatments

PM George, GK Steinberg - Neuron, 2015 - cell.com
Stroke remains a leading cause of death and disability in the world. Over the past few
decades our understanding of the pathophysiology of stroke has increased, but greater …

Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: a phase 1/2a trial

RH Baloh, JP Johnson, P Avalos, P Allred… - Nature medicine, 2022 - nature.com
Amyotrophic lateral sclerosis (ALS) involves progressive motor neuron loss, leading to
paralysis and death typically within 3–5 years of diagnosis. Dysfunctional astrocytes may …

[HTML][HTML] The stem cell secretome and its role in brain repair

D Drago, C Cossetti, N Iraci, E Gaude, G Musco… - Biochimie, 2013 - Elsevier
Compelling evidence exists that non-haematopoietic stem cells, including mesenchymal
(MSCs) and neural/progenitor stem cells (NPCs), exert a substantial beneficial and …

Cell therapy for neurological disorders

SP Svendsen, CN Svendsen - Nature Medicine, 2024 - nature.com
Cell therapies for neurological disorders are entering the clinic and present unique
challenges and opportunities compared with conventional medicines. They have the …

Neural stem cell therapy for subacute and chronic ischemic stroke

AC Boese, QSE Le, D Pham, MH Hamblin… - Stem cell research & …, 2018 - Springer
Neural stem cells (NSCs) play vital roles in brain homeostasis and exhibit a broad repertoire
of potentially therapeutic actions following neurovascular injury. One such injury is stroke, a …

A review of exercise-induced neuroplasticity in ischemic stroke: pathology and mechanisms

Y **ng, Y Bai - Molecular Neurobiology, 2020 - Springer
After ischemic stroke, survivors experience motor dysfunction and deterioration of memory
and cognition. These symptoms are associated with the disruption of normal neuronal …

Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation

DM Hermann, M Chopp - The Lancet Neurology, 2012 - thelancet.com
Recent laboratory findings suggest that it might be possible to promote cerebral plasticity
and neurological recovery after stroke by use of exogenous pharmacological or cell-based …

Enhancing brain plasticity to promote stroke recovery

F Su, W Xu - Frontiers in neurology, 2020 - frontiersin.org
Stroke disturbs both the structural and functional integrity of the brain. The understanding of
stroke pathophysiology has improved greatly in the past several decades. However …

Multicellular crosstalk between exosomes and the neurovascular unit after cerebral ischemia. Therapeutic implications

AM Zagrean, DM Hermann, I Opris, L Zagrean… - Frontiers in …, 2018 - frontiersin.org
Restorative strategies after stroke are focused on the remodeling of cerebral endothelial
cells and brain parenchymal cells. The latter, ie, neurons, neural precursor cells and glial …