Microglia and monocytes/macrophages polarization reveal novel therapeutic mechanism against stroke
M Kanazawa, I Ninomiya, M Hatakeyama… - International journal of …, 2017 - mdpi.com
Stroke is a leading cause of morbidity and mortality worldwide, and consists of two types,
ischemic and hemorrhagic. Currently, there is no effective treatment to increase the survival …
ischemic and hemorrhagic. Currently, there is no effective treatment to increase the survival …
Novel stroke therapeutics: unraveling stroke pathophysiology and its impact on clinical treatments
PM George, GK Steinberg - Neuron, 2015 - cell.com
Stroke remains a leading cause of death and disability in the world. Over the past few
decades our understanding of the pathophysiology of stroke has increased, but greater …
decades our understanding of the pathophysiology of stroke has increased, but greater …
Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: a phase 1/2a trial
RH Baloh, JP Johnson, P Avalos, P Allred… - Nature medicine, 2022 - nature.com
Amyotrophic lateral sclerosis (ALS) involves progressive motor neuron loss, leading to
paralysis and death typically within 3–5 years of diagnosis. Dysfunctional astrocytes may …
paralysis and death typically within 3–5 years of diagnosis. Dysfunctional astrocytes may …
[HTML][HTML] The stem cell secretome and its role in brain repair
Compelling evidence exists that non-haematopoietic stem cells, including mesenchymal
(MSCs) and neural/progenitor stem cells (NPCs), exert a substantial beneficial and …
(MSCs) and neural/progenitor stem cells (NPCs), exert a substantial beneficial and …
Cell therapy for neurological disorders
SP Svendsen, CN Svendsen - Nature Medicine, 2024 - nature.com
Cell therapies for neurological disorders are entering the clinic and present unique
challenges and opportunities compared with conventional medicines. They have the …
challenges and opportunities compared with conventional medicines. They have the …
Neural stem cell therapy for subacute and chronic ischemic stroke
AC Boese, QSE Le, D Pham, MH Hamblin… - Stem cell research & …, 2018 - Springer
Neural stem cells (NSCs) play vital roles in brain homeostasis and exhibit a broad repertoire
of potentially therapeutic actions following neurovascular injury. One such injury is stroke, a …
of potentially therapeutic actions following neurovascular injury. One such injury is stroke, a …
A review of exercise-induced neuroplasticity in ischemic stroke: pathology and mechanisms
Y **ng, Y Bai - Molecular Neurobiology, 2020 - Springer
After ischemic stroke, survivors experience motor dysfunction and deterioration of memory
and cognition. These symptoms are associated with the disruption of normal neuronal …
and cognition. These symptoms are associated with the disruption of normal neuronal …
Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation
Recent laboratory findings suggest that it might be possible to promote cerebral plasticity
and neurological recovery after stroke by use of exogenous pharmacological or cell-based …
and neurological recovery after stroke by use of exogenous pharmacological or cell-based …
Enhancing brain plasticity to promote stroke recovery
F Su, W Xu - Frontiers in neurology, 2020 - frontiersin.org
Stroke disturbs both the structural and functional integrity of the brain. The understanding of
stroke pathophysiology has improved greatly in the past several decades. However …
stroke pathophysiology has improved greatly in the past several decades. However …
Multicellular crosstalk between exosomes and the neurovascular unit after cerebral ischemia. Therapeutic implications
Restorative strategies after stroke are focused on the remodeling of cerebral endothelial
cells and brain parenchymal cells. The latter, ie, neurons, neural precursor cells and glial …
cells and brain parenchymal cells. The latter, ie, neurons, neural precursor cells and glial …