It is more effective to maintain good health than to regain it after losing it. This work focuses
on the biochemical defense mechanisms against free radicals and their role in building and …

Urease is an attractive drug target for designing anti-infective agents against pathogens
such as Helicobacter pylori, Proteus mirabilis, and Ureaplasma urealyticum. In the past …

In the present study, 28 acyl hydrazones (4–31) of flurbiprofen were synthesized in good to
excellent yield by reacting different aromatic aldehydes with the commercially available drug …

Urease is the main virulence factor of infectious gastritis and gastric ulcers. Urease inhibitors
are regarded as the first choice for the treatment of such diseases. Based on the triazolone …

Abstract Mannich bases consisting of 1, 3, 4‐oxadiazole‐2‐thione (3 a–3 l) bearing various
substituents were synthesized and found potent jack bean urease inhibitors. The prepared …

With expanding recent outbreaks and a lack of treatment options, the Zika virus (ZIKV) poses
a severe health concern. The availability of ZIKV NS2B-NS3 co-crystallized structures paved …

Rift valley fever virus (RVFV) is the causative agent of a viral zoonosis that causes a
significant clinical burden in domestic and wild ruminants. Major outbreaks of the virus occur …

Abstract Thirty-three (N-aryl-N-arylsulfonyl) aminoacetohydroxamic acids were synthesized
in an effort to develop novel urease inhibitors. Among these compounds, 2-(N-(3 …

Salvinia cucullata is a freshwater weed available abundantly in nature and also a
troublesome aquatic weed globally. This study was conducted to know the chances of using …

We previously demonstrated that 50% of children with obesity from consanguineous families
from Pakistan carry pathogenic variants in known monogenic obesity genes. Here, we have …