Sex and gender disparities in the epidemiology and outcomes of chronic kidney disease
Improved understanding of sex and gender-specific differences in the aetiology,
mechanisms and epidemiology of chronic kidney disease (CKD) could help nephrologists …
mechanisms and epidemiology of chronic kidney disease (CKD) could help nephrologists …
Evolution of the immune system in humans from infancy to old age
This article reviews the development of the immune response through neonatal, infant and
adult life, including pregnancy, ending with the decline in old age. A picture emerges of a …
adult life, including pregnancy, ending with the decline in old age. A picture emerges of a …
Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2
During gestation the develo** human fetus is exposed to a diverse range of potentially
immune-stimulatory molecules including semi-allogeneic antigens from maternal cells …
immune-stimulatory molecules including semi-allogeneic antigens from maternal cells …
Immunological implications of pregnancy-induced microchimerism
Immunological identity is traditionally defined by genetically encoded antigens, with equal
maternal and paternal contributions as a result of Mendelian inheritance. However, vertically …
maternal and paternal contributions as a result of Mendelian inheritance. However, vertically …
New paradigm in the role of regulatory T cells during pregnancy
S Tsuda, A Nakashima, T Shima, S Saito - Frontiers in immunology, 2019 - frontiersin.org
Semi-allogenic fetuses are not rejected by the maternal immune system because feto-
maternal tolerance induced by CD4+ CD25+ FoxP3+ regulatory T (Treg) cells is established …
maternal tolerance induced by CD4+ CD25+ FoxP3+ regulatory T (Treg) cells is established …
Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero
As the immune system develops, T cells are selected or regulated to become tolerant of self
antigens and reactive against foreign antigens. In mice, the induction of such tolerance is …
antigens and reactive against foreign antigens. In mice, the induction of such tolerance is …
The maternal gut microbiome during pregnancy and offspring allergy and asthma
Environmental exposures during pregnancy that alter both the maternal gut microbiome and
the infant's risk of allergic disease and asthma include a traditional farm environment and …
the infant's risk of allergic disease and asthma include a traditional farm environment and …
Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans
JE Mold, S Venkatasubrahmanyam, TD Burt… - Science, 2010 - science.org
Although the mammalian immune system is generally thought to develop in a linear fashion,
findings in avian and murine species argue instead for the developmentally ordered …
findings in avian and murine species argue instead for the developmentally ordered …
The European Society for Blood and Marrow Transplantation (EBMT) consensus recommendations for donor selection in haploidentical hematopoietic cell …
The number of HLA-haploidentical hematopoietic cell transplants continues to increase
worldwide due to recent improvements in outcomes, allowing more patients with …
worldwide due to recent improvements in outcomes, allowing more patients with …
Genetics of rheumatoid arthritis: what have we learned?
Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 0.5–1% of the
population worldwide. The disease has a heterogeneous character, including clinical …
population worldwide. The disease has a heterogeneous character, including clinical …