The Caenorhabditis elegans Transgenic Toolbox

J Nance, C Frøkjær-Jensen - Genetics, 2019 - academic.oup.com
The power of any genetic model organism is derived, in part, from the ease with which gene
expression can be manipulated. The short generation time and invariant developmental …

The biogenesis and biological function of PIWI-interacting RNA in cancer

S Chen, S Ben, J **n, S Li, R Zheng, H Wang… - Journal of hematology & …, 2021 - Springer
Small non-coding RNAs (ncRNAs) are vital regulators of biological activities, and aberrant
levels of small ncRNAs are commonly found in precancerous lesions and cancer. PIWI …

piRBase: a comprehensive database of piRNA sequences

J Wang, P Zhang, Y Lu, Y Li, Y Zheng… - Nucleic acids …, 2019 - academic.oup.com
PIWI-interacting RNAs are a class of small RNAs that is most abundantly expressed in
animal germline. Substantial research is going on to reveal the functions of piRNAs in the …

Engineering rules that minimize germline silencing of transgenes in simple extrachromosomal arrays in C. elegans

MD Aljohani, S El Mouridi, M Priyadarshini… - Nature …, 2020 - nature.com
Transgenes are prone to progressive silencing due to their structure, copy number, and
genomic location. In C. elegans, repressive mechanisms are particularly strong in the …

A tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans

KI Manage, AK Rogers, DC Wallis, CJ Uebel… - Elife, 2020 - elifesciences.org
piRNAs play a critical role in the regulation of transposons and other germline genes. In
Caenorhabditis elegans, regulation of piRNA target genes is mediated by the mutator …

A review of discovery profiling of PIWI-interacting RNAs and their diverse functions in metazoans

S Huang, K Yoshitake, S Asakawa - International Journal of Molecular …, 2021 - mdpi.com
PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs (sncRNAs) that
perform crucial biological functions in metazoans and defend against transposable elements …

piR-823 tale as emerging cancer-hallmark molecular marker in different cancer types: a step-toward ncRNA-precision

FH Shaker, EF Sanad, H Elghazaly, SM Hsia… - Naunyn-Schmiedeberg's …, 2024 - Springer
PIWI-interacting RNAs (piRNAs) have received a lot of attention for their functions in cancer
research. This class of short non-coding RNAs (ncRNA) has roles in genomic stability …

Split-wrmScarlet and split-sfGFP: tools for faster, easier fluorescent labeling of endogenous proteins in Caenorhabditis elegans

J Goudeau, CS Sharp, J Paw, L Savy, MD Leonetti… - Genetics, 2021 - academic.oup.com
We create and share a new red fluorophore, along with a set of strains, reagents and
protocols, to make it faster and easier to label endogenous Caenorhabditis elegans proteins …

[HTML][HTML] Identification of piRNA disease associations using deep learning

SD Ali, H Tayara, KT Chong - Computational and Structural Biotechnology …, 2022 - Elsevier
Piwi-interacting RNAs (piRNAs) play a pivotal role in maintaining genome integrity by
repression of transposable elements, gene stability, and association with various disease …

piRTarBase: a database of piRNA targeting sites and their roles in gene regulation

WS Wu, JS Brown, TT Chen, YH Chu… - Nucleic acids …, 2019 - academic.oup.com
PIWI-interacting RNAs (piRNAs) are a class of small noncoding RNAs that guard animal
genomes against mutation by silencing transposons. In addition, recent studies have …