Atherosclerosis, characterized by lipid‐rich plaques in the arterial wall, is an age‐related
disorder and a leading cause of mortality worldwide. However, the specific mechanisms …

Diabetes is well established as a chronic disease with a high health burden due to mortality
or morbidity from the final outcomes of vascular complications. An increased duration of …

The incidence of type 2 diabetes mellitus is growing in epidemic proportions and has
become one of the most critical public health concerns. Cardiovascular complications …

Vascular aging represents a collection of structural and functional changes in a blood vessel
with advancing age, including increased stiffness, vascular wall remodeling, loss of …

The crosstalk of the heart with distant organs such as the lung, liver, gut, and kidney has
been intensively approached lately. The kidney is involved in (1) the production of systemic …

Amidst several pathophysiological cascades, Advanced Glycation End products (AGEs)
have been identified as a pivotal aetiology behind the pathogenesis and progression of …

Epidemiological studies demonstrate the role of early and intensive glycemic control in the
prevention of micro and macrovascular disease in both type 1 and type 2 diabetes mellitus …

Methylglyoxal (MGO) is a highly reactive α-dicarbonyl compound formed endogenously from
3-carbon glycolytic intermediates. Methylglyoxal accumulated in plasma and urine of …

Advanced Glycation End Products (AGEs) contribute to the pathophysiology of type 2
diabetes mellitus (T2DM) and cardiovascular (CV) diseases (CVDs), making their non …

Nitric oxide (NO), a vasodilator contributes to the vaso-occlusive crisis associated with the
sickle cell disease (SCD). Vascular nitric oxide helps in vasodilation, controlled platelet …