In this review, we highlight the role of intratumoral heterogeneity, focusing on the clinical and
biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through …

The past several years have seen dramatic leaps in our understanding of how gene
expression is rewired at the translation level during tumorigenesis to support the …

Cellular stress is an intrinsic part of cell physiology that underlines cell survival or death. The
ability of mammalian cells to regulate global protein synthesis (aka translational control) …

Injury-induced sensitization of nociceptors contributes to pain states and the development of
chronic pain. Inhibiting activity-dependent mRNA translation through mechanistic target of …

Pancreatic cancer (pancreatic ductal adenocarcinoma, PDA) is infamously moving to the top
of the list as one of the most lethal cancers with an overall 5 year survival rate of 7%. Multiple …

The eIF4F complex regulates the cap-dependent mRNA translation process. It is becoming
increasingly evident that aberrant activity of this complex is observed in many cancers …

The evidence for the importance of aberrant translation in cancer cells is overwhelming.
Reflecting the wealth of data, there are excellent reviews delineating how ribosomes and …

It is increasingly appreciated that alternative splicing plays a key role in generating
functional specificity and diversity in cancer. However, the mechanisms by which cancer …

The assembly of stress granules (SGs) is a conserved mechanism to regulate protein
synthesis under cell stress, where the translation of global protein is silenced and selective …

Background Tissue inhibitors of metalloproteinase (TIMP) family proteins are peptidases
involved in extracellular matrix (ECM) degradation. Various diseases are related to TIMPs …