Cortisol, a critical glucocorticoid hormone produced by the adrenal glands, plays a pivotal
role in various physiological processes. Its release is finely orchestrated by the …

Repetitive brain trauma is associated with a progressive neurological deterioration, now
termed as chronic traumatic encephalopathy (CTE). Most instances of CTE occur in …

Objective: Alzheimer's disease (AD), the most important progressive neurodegenerative
disorder, is characterized by cognitive and behavioral disabilities. Nowadays, tau, as a …

The benefits of regular exercise, physical fitness and sports participation on cardiovascular
and brain health are undeniable. Physical activity reduces the risk for cardiovascular …

Stress and stress hormones, glucocorticoids (GCs), exert widespread actions in central
nervous system, ranging from the regulation of gene transcription, cellular signaling …

The microtubule-associated protein tau is integral to the pathogenesis of Alzheimer's
disease (AD), as well as several related disorders, termed tauopathies, in which tau is …

Chronic psychosocial stress is increasingly being recognised as a risk factor for sporadic
Alzheimer's disease (AD). The hypothalamic–pituitary–adrenal axis (HPA axis) is the major …

Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease that
occurs in association with repetitive traumatic brain injury experienced in sport and military …

There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …

Prolonged exposure to glucocorticoids, the main stress hormones, damages the brain and is
a risk factor for depression and Alzheimer's disease. Two major drivers of glucocorticoid …