Pathophysiology of hypertension: the mosaic theory and beyond

DG Harrison, TM Coffman, CS Wilcox - Circulation research, 2021 - Am Heart Assoc
Dr Irvine Page proposed the Mosaic Theory of Hypertension in the 1940s advocating that
hypertension is the result of many factors that interact to raise blood pressure and cause end …

Resistant hypertension: detection, evaluation, and management: a scientific statement from the American Heart Association

RM Carey, DA Calhoun, GL Bakris, RD Brook… - …, 2018 - Am Heart Assoc
Resistant hypertension (RH) is defined as above-goal elevated blood pressure (BP) in a
patient despite the concurrent use of 3 antihypertensive drug classes, commonly including a …

Understanding the complexity of heart failure risk and treatment in black patients

A Nayak, AJ Hicks, AA Morris - Circulation: Heart Failure, 2020 - Am Heart Assoc
Although care of patients with heart failure (HF) has improved in the past decade, important
disparities in HF outcomes persist based on race/ethnicity. Age-adjusted HF-related …

Hypertension: do inflammation and immunity hold the key to solving this epidemic?

MS Madhur, F Elijovich, MR Alexander, A Pitzer… - Circulation …, 2021 - Am Heart Assoc
Elevated cardiovascular risk including stroke, heart failure, and heart attack is present even
after normalization of blood pressure in patients with hypertension. Underlying immune cell …

Effect of dietary sodium on blood pressure: a crossover trial

DK Gupta, CE Lewis, KA Varady, YR Su, MS Madhur… - JAMA, 2023 - jamanetwork.com
Importance Dietary sodium recommendations are debated partly due to variable blood
pressure (BP) response to sodium intake. Furthermore, the BP effect of dietary sodium …

Animal models of hypertension: a scientific statement from the American Heart Association

LO Lerman, TW Kurtz, RM Touyz, DH Ellison… - …, 2019 - Am Heart Assoc
Hypertension is the most common chronic disease in the world, yet the precise cause of
elevated blood pressure often cannot be determined. Animal models have been useful for …

[HTML][HTML] Redefining diuretics use in hypertension: why select a thiazide-like diuretic?

M Burnier, G Bakris, B Williams - Journal of hypertension, 2019 - journals.lww.com
Diuretics are listed in hypertension guidelines as one of three equally weighted first-line
treatment options. In order to differentiate between antihypertensives, a lot of discussion has …

Salt sensitivity of blood pressure in women

CT Barris, JL Faulkner, EJ Belin de Chantemèle - Hypertension, 2023 - Am Heart Assoc
Several clinical and large population studies indicate that women are more salt-sensitive
than men, yet the precise mechanisms by which the sexually dimorphic onset manifests …

Salt sensitivity: causes, consequences, and recent advances

MA Bailey, N Dhaun - Hypertension, 2024 - Am Heart Assoc
Salt (sodium chloride) is an essential nutrient required to maintain physiological functions.
However, for most people, daily salt intake far exceeds their physiological need and is …