Metagenomics for neurological infections—expanding our imagination

PS Ramachandran, MR Wilson - Nature Reviews Neurology, 2020 - nature.com
Over the past two decades, the diagnosis rate for patients with encephalitis has remained
poor despite advances in pathogen-specific testing such as PCR and antigen assays …

Surface modification of SiO2 nanoparticles for bacterial decontaminations of blood products

M Alavi, MR Hamblin, MR Mozafari… - Cellular, Molecular …, 2022 - cmbr-journal.com
Bacterial infections can be caused by contamination of labile blood products with specific
bacteria, such as Staphylococcus aureus and Staphylococcus epidermidis. Hospital …

IDseq—An open source cloud-based pipeline and analysis service for metagenomic pathogen detection and monitoring

KL Kalantar, T Carvalho, CFA de Bourcy… - …, 2020 - academic.oup.com
Background Metagenomic next-generation sequencing (mNGS) has enabled the rapid,
unbiased detection and identification of microbes without pathogen-specific reagents …

Increased rates of secondary bacterial infections, including Enterococcus bacteremia, in patients hospitalized with coronavirus disease 2019 (COVID-19)

C DeVoe, MR Segal, L Wang, K Stanley… - Infection Control & …, 2022 - cambridge.org
Objective: We compared the rates of hospital-onset secondary bacterial infections in patients
with coronavirus disease 2019 (COVID-19) with rates in patients with influenza and controls …

Posttransfusion sepsis attributable to bacterial contamination in platelet collection set manufacturing facility, United States

I Kracalik, AG Kent, CH Villa, P Gable… - Emerging Infectious …, 2023 - pmc.ncbi.nlm.nih.gov
During May 2018‒December 2022, we reviewed transfusion-transmitted sepsis cases in the
United States attributable to polymicrobial contaminated apheresis platelet components …

Application of mNGS in the etiological diagnosis of thoracic and abdominal infection in patients with end-stage liver disease

H Chen, Y Zhang, J Zheng, L Shi, Y He… - Frontiers in cellular …, 2022 - frontiersin.org
Background Despite the obvious advantages of metagenomic next-generation sequencing
(mNGS) in etiological diagnosis of various infectious diseases, there are few reports on …

Use of unbiased metagenomic and transcriptomic analyses to investigate the association between feline calicivirus and feline chronic gingivostomatitis in domestic …

WA Fried, M Soltero-Rivera, A Ramesh… - American journal of …, 2021 - Am Vet Med Assoc
OBJECTIVE To identify associations between microbes and host genes in cats with feline
chronic gingivostomatitis (FCGS), a debilitating inflammatory oral mucosal disease with no …

Development and clinical validation of a droplet digital PCR assay for detecting Acinetobacter baumannii and Klebsiella pneumoniae in patients with suspected …

Y Zheng, J **, Z Shao, J Liu, R Zhang… - …, 2021 - Wiley Online Library
The relatively long turnaround time and low sensitivity of traditional blood culture‐based
diagnosis may delay effective antibiotic therapy for patients with bloodstream infections …

In host evolution of beta lactam resistance during active treatment for Pseudomonas aeruginosa bacteremia

N Spottiswoode, S Hao, E Sanchez-Guerrero… - Frontiers in Cellular …, 2023 - frontiersin.org
Multidrug-resistant (MDR) Pseudomonas aeruginosa has been declared a serious threat by
the United States Centers for Disease Control and Prevention. Here, we used whole …

Sepsis from an apheresis platelet contaminated with Acinetobacter calcoaceticus/baumannii complex bacteria and Staphylococcus saprophyticus after pathogen …

JL Fridey, SL Stramer, A Nambiar, M Moayeri… - …, 2020 - Wiley Online Library
Background Strategies to reduce platelet (PLT) bacterial contamination include donor
screening, skin disinfection, sample diversion, bacterial culture, pathogen reduction (PR) …