Biomarker-based staging of Alzheimer disease: rationale and clinical applications

J Therriault, SE Schindler, G Salvadó… - Nature Reviews …, 2024 - nature.com
Disease staging, whereby the spatial extent and load of brain pathology are used to
estimate the severity of Alzheimer disease (AD), is pivotal to the gold-standard …

Amyloid and tau‐PET in early‐onset AD: baseline data from the Longitudinal Early‐onset Alzheimer's Disease Study (LEADS)

H Cho, NS Mundada, LG Apostolova… - Alzheimer's & …, 2023 - Wiley Online Library
INTRODUCTION We aimed to describe baseline amyloid‐beta (Aβ) and tau‐positron
emission tomograrphy (PET) from Longitudinal Early‐onset Alzheimer's Disease Study …

Tau accumulation and its spatial progression across the Alzheimer's disease spectrum

F St-Onge, M Chapleau, JCS Breitner… - Brain …, 2024 - academic.oup.com
The accumulation of tau abnormality in sporadic Alzheimer's disease is believed typically to
follow neuropathologically defined Braak staging. Recent in-vivo PET evidence challenges …

Association of Loneliness with Functional Connectivity MRI, Amyloid-β PET, and Tau PET Neuroimaging Markers of Vulnerability for Alzheimer's Disease

A Zhao, LJ Balcer, JJ Himali… - Journal of …, 2024 - journals.sagepub.com
Background: Loneliness has been declared an “epidemic” associated with negative
physical, mental, and cognitive health outcomes such as increased dementia risk. Less is …

Generative adversarial network–enhanced ultra-low-dose [18F]-PI-2620 τ PET/MRI in aging and neurodegenerative populations

KT Chen, R Tesfay, MEI Koran, J Ouyang… - American Journal of …, 2023 - ajnr.org
BACKGROUND AND PURPOSE: With the utility of hybrid τ PET/MR imaging in the
screening, diagnosis, and follow-up of individuals with neurodegenerative diseases, we …

Spatial and temporal patterns of cortical mean diffusivity in Alzheimer's disease and suspected non‐Alzheimer's disease pathophysiology

P Sun, Z He, A Li, J Yang, Y Zhu, Y Cai… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION The spatial and temporal patterns of cortical mean diffusivity (cMD), as well
as its association with Alzheimer's disease (AD) and suspected non‐Alzheimer's …

Contribution of Alzheimer's disease pathology to biological and clinical progression: A longitudinal study across two cohorts

W Zhang, HF Wang, K Kuo, L Wang, Y Li… - Alzheimer's & …, 2023 - Wiley Online Library
INTRODUCTION Amyloid beta (Aβ) deposition, tau accumulation, and brain atrophy occurr
in sequence, but the contribution of Alzheimer's disease (AD) pathology to biological and …

Spatial extent as a sensitive amyloid‐PET metric in preclinical Alzheimer's disease

ME Farrell, EG Thibault, JA Becker… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Spatial extent‐based measures of how far amyloid beta (Aβ) has spread
throughout the neocortex may be more sensitive than traditional Aβ‐positron emission …

Clinical outcomes of increased focal amyloid uptake in individuals with subthreshold global amyloid levels

J Kim, YS Choe, Y Park, Y Kim, JP Kim… - Frontiers in Aging …, 2023 - frontiersin.org
Background Although the standardized uptake value ratio (SUVR) method is objective and
simple, cut-off optimization using global SUVR values may not reflect focal increased uptake …

Expression of regional brain amyloid-β deposition with [18F]Flutemetamol in Centiloid scale -a multi-site study

YW Bao, ZJ Wang, LL Guo, GJ Bai, Y Feng, GD Zhao - Neuroradiology, 2024 - Springer
Abstract Purpose The Centiloid project helps calibrate the quantitative amyloid-β (Aβ) load
into a unified Centiloid (CL) scale that allows data comparison across multi-site. How the …