Receptors enable cells to detect, process and respond to information about their
environments. Over the past two decades, synthetic biologists have repurposed physical …

Synthetic biology is the discipline of engineering application-driven biological functionalities
that were not evolved by nature. Early breakthroughs of cell engineering, which were based …

Synthetic biology aims to design or assemble existing bioparts or bio-components for useful
bioproperties. During the past decades, progresses have been made to build delicate …

Strategies for expanding the sensor space of designer receptors are urgently needed to
tailor cell-based therapies to respond to any type of medically relevant molecules. Here, we …

Traceless physical cues are desirable for remote control of the in situ production and real-
time dosing of biopharmaceuticals in cell-based therapies. However, current optogenetic …

In living organisms, naturally evolved sensors that constantly monitor and process
environmental cues trigger corrective actions that enable the organisms to cope with …

Engineered immune-cell-based cancer therapies have demonstrated robust efficacy in B
cell malignancies, but challenges such as the lack of ideal targetable tumour antigens …

T-cell-based immunotherapy, such as CAR-T cells and bispecific T-cell engagers (BiTEs),
has shown promising clinical outcomes in many cancers; however, these therapies have …

Cell therapy approaches that employ engineered mammalian cells for on-demand
production of therapeutic agents in the patient's body are moving beyond proof-of-concept in …

Advances in genomic sequencing and bioinformatics have led to the prospect of precision
medicine where therapeutics can be advised by the genetic background of individuals. For …