Critical care uses syndromic definitions to describe patient groups for clinical practice and
research. There is growing recognition that a “precision medicine” approach is required and …

Frequentist and Bayesian statistics represent two differing paradigms for the analysis of
data. Frequentism became the dominant mode of statistical thinking in medical practice …

Importance Among critically ill adults, randomized trials have not found oxygenation targets
to affect outcomes overall. Whether the effects of oxygenation targets differ based on an …

Background We sought to estimate whether a lower mean arterial blood pressure target,
compared with a higher mean arterial blood pressure target, reduced 90-day all-cause …

This scientific statement presents a conceptual framework for the pathophysiology of post–
cardiac arrest brain injury, explores reasons for previous failure to translate preclinical data …

Introduction When the COVID-19 pandemic struck no specific therapies were available and
many turned to COVID-19 convalescent plasma (CCP), a form of antibody therapy. The …

Three years after the start of the pandemic, approaches to the prevention and treatment of
acute Covid-19 have been established. However, post-acute sequelae of SARS-CoV-2 …

Sepsis is accompanied by thrombocytopenia and the severity of the thrombocytopenia is
associated with mortality. This thrombocytopenia is characteristic of disseminated …

Based on emerging evidence from the COVID-19 pandemic, the International Society on
Thrombosis and Haemostasis (ISTH) guidelines for antithrombotic treatment in COVID-19 …

Clinicians know that individual patients may respond differently to a given treatment and that
the overall treatment effect reported in a randomized trial of the treatment may not be directly …