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A field guide to flow chemistry for synthetic organic chemists
Flow chemistry has unlocked a world of possibilities for the synthetic community, but the idea
that it is a mysterious “black box” needs to go. In this review, we show that several of the …
that it is a mysterious “black box” needs to go. In this review, we show that several of the …
The hitchhiker's guide to flow chemistry∥
Flow chemistry involves the use of channels or tubing to conduct a reaction in a continuous
stream rather than in a flask. Flow equipment provides chemists with unique control over …
stream rather than in a flask. Flow equipment provides chemists with unique control over …
Emerging trends in flow chemistry and applications to the pharmaceutical industry
AR Bogdan, AW Dombrowski - Journal of medicinal chemistry, 2019 - ACS Publications
The field of flow chemistry has garnered considerable attention over the past 2 decades.
This Perspective highlights many recent advances in the field of flow chemistry and …
This Perspective highlights many recent advances in the field of flow chemistry and …
The application of modern reactions in large-scale synthesis
K Lovato, PS Fier, KM Maloney - Nature Reviews Chemistry, 2021 - nature.com
In the past decade, the field of organic synthesis has witnessed tremendous advancements
in the areas of photoredox catalysis, electrochemistry, C–H activation, reductive coupling …
in the areas of photoredox catalysis, electrochemistry, C–H activation, reductive coupling …
The evolving state of continuous processing in pharmaceutical API manufacturing: a survey of pharmaceutical companies and contract manufacturing organizations
JC McWilliams, AD Allian, SM Opalka… - … Process Research & …, 2018 - ACS Publications
This manuscript provides the results of an in-depth survey assessment of the capabilities,
experience, and perspectives on continuous processing in the pharmaceutical sector, with …
experience, and perspectives on continuous processing in the pharmaceutical sector, with …
Scaling continuous API synthesis from milligram to kilogram: extending the enabling benefits of micro to the plant
M Berton, JM de Souza, I Abdiaj, DT McQuade… - Journal of Flow …, 2020 - Springer
The signature benefits of continuous flow are largely a result of a reactor's micro-sized
features. However, as the technology gains industrial traction in the synthesis of active …
features. However, as the technology gains industrial traction in the synthesis of active …
Flow chemistry, continuous processing, and continuous manufacturing: A pharmaceutical perspective
SA May - Journal of Flow Chemistry, 2017 - akjournals.com
Flow chemistry has become a vibrant area for research over the past decade. This
perspective is intended to capture insights on how these advances have and will continue to …
perspective is intended to capture insights on how these advances have and will continue to …
Continuous Flow Chemistry with Solids: A Review
HLD Hayes, CJ Mallia - Organic Process Research & …, 2024 - ACS Publications
The effective handling of solids in a continuous flow process is one of the biggest perceived
challenges remaining for modern flow chemistry. This Review aims to consider some of the …
challenges remaining for modern flow chemistry. This Review aims to consider some of the …
Automated optimization under dynamic flow conditions
Automated optimization in flow reactors is a technology that continues to gain interest in
academic and industrial research. For drug substance applications, where limited material is …
academic and industrial research. For drug substance applications, where limited material is …
Continuous flow technology vs. the batch-by-batch approach to produce pharmaceutical compounds
KP Cole, MD Johnson - Expert review of clinical pharmacology, 2018 - Taylor & Francis
Introduction: For the manufacture of small molecule drugs, many pharmaceutical innovator
companies have recently invested in continuous processing, which can offer significant …
companies have recently invested in continuous processing, which can offer significant …