A field guide to flow chemistry for synthetic organic chemists

L Capaldo, Z Wen, T Noël - Chemical science, 2023 - pubs.rsc.org
Flow chemistry has unlocked a world of possibilities for the synthetic community, but the idea
that it is a mysterious “black box” needs to go. In this review, we show that several of the …

The hitchhiker's guide to flow chemistry∥

MB Plutschack, B Pieber, K Gilmore… - Chemical …, 2017 - ACS Publications
Flow chemistry involves the use of channels or tubing to conduct a reaction in a continuous
stream rather than in a flask. Flow equipment provides chemists with unique control over …

Emerging trends in flow chemistry and applications to the pharmaceutical industry

AR Bogdan, AW Dombrowski - Journal of medicinal chemistry, 2019 - ACS Publications
The field of flow chemistry has garnered considerable attention over the past 2 decades.
This Perspective highlights many recent advances in the field of flow chemistry and …

The application of modern reactions in large-scale synthesis

K Lovato, PS Fier, KM Maloney - Nature Reviews Chemistry, 2021 - nature.com
In the past decade, the field of organic synthesis has witnessed tremendous advancements
in the areas of photoredox catalysis, electrochemistry, C–H activation, reductive coupling …

The evolving state of continuous processing in pharmaceutical API manufacturing: a survey of pharmaceutical companies and contract manufacturing organizations

JC McWilliams, AD Allian, SM Opalka… - … Process Research & …, 2018 - ACS Publications
This manuscript provides the results of an in-depth survey assessment of the capabilities,
experience, and perspectives on continuous processing in the pharmaceutical sector, with …

Scaling continuous API synthesis from milligram to kilogram: extending the enabling benefits of micro to the plant

M Berton, JM de Souza, I Abdiaj, DT McQuade… - Journal of Flow …, 2020 - Springer
The signature benefits of continuous flow are largely a result of a reactor's micro-sized
features. However, as the technology gains industrial traction in the synthesis of active …

Flow chemistry, continuous processing, and continuous manufacturing: A pharmaceutical perspective

SA May - Journal of Flow Chemistry, 2017 - akjournals.com
Flow chemistry has become a vibrant area for research over the past decade. This
perspective is intended to capture insights on how these advances have and will continue to …

Continuous Flow Chemistry with Solids: A Review

HLD Hayes, CJ Mallia - Organic Process Research & …, 2024 - ACS Publications
The effective handling of solids in a continuous flow process is one of the biggest perceived
challenges remaining for modern flow chemistry. This Review aims to consider some of the …

Automated optimization under dynamic flow conditions

JP McMullen, BM Wyvratt - Reaction Chemistry & Engineering, 2023 - pubs.rsc.org
Automated optimization in flow reactors is a technology that continues to gain interest in
academic and industrial research. For drug substance applications, where limited material is …

Continuous flow technology vs. the batch-by-batch approach to produce pharmaceutical compounds

KP Cole, MD Johnson - Expert review of clinical pharmacology, 2018 - Taylor & Francis
Introduction: For the manufacture of small molecule drugs, many pharmaceutical innovator
companies have recently invested in continuous processing, which can offer significant …