Abstract ARIC (Atherosclerosis Risk In Communities) initiated community-based
surveillance in 1987 for myocardial infarction and coronary heart disease (CHD) incidence …

Investigative genetic genealogy (IGG) has emerged as a new, rapidly growing field of
forensic science. We describe the process whereby dense SNP data, commonly comprising …

Genotype imputation is commonly performed in genome-wide association studies because it
greatly increases the number of markers that can be tested for association with a trait. In …

Low-coverage whole-genome sequencing followed by imputation has been proposed as a
cost-effective genoty** approach for disease and population genetics studies. However …

OBJECTIVE Previously generated genetic risk scores (GRSs) for type 1 diabetes (T1D) have
not captured all known information at non-HLA loci or, particularly, at HLA risk loci. We …

Protein-coding genetic variants that strongly affect disease risk can yield relevant clues to
disease pathogenesis. Here we report exome-sequencing analyses of 20,791 individuals …

Genotype imputation is the process of predicting unobserved genotypes in a sample of
individuals using a reference panel of haplotypes. In the last 10 years reference panels have …

Highlights•Pan-genomes represent the complex genomic diversity found in plant
species.•Novel approaches are under development to enable more complex pan-genome …

Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disease. Due to
its long clinical course and lack of an effective treatment, AD has become a major public …

Genetic studies on telomere length are important for understanding age-related diseases.
Prior GWASs for leukocyte TL have been limited to European and Asian populations. Here …