The role of chemistry in the development of boron neutron capture therapy of cancer

MF Hawthorne - Angewandte Chemie International Edition in …, 1993 - Wiley Online Library
A therapeutic method that selectively destroys malignant cells in the presence of normal
cells is a highly valued goal of oncologists and the possible salvation of cancer patients …

Peptide nucleic acids (PNA). Oligonucleotide analogs with an achiral peptide backbone

M Egholm, O Buchardt, PE Nielsen… - Journal of the American …, 1992 - ACS Publications
ArbMB282 [l (l+ l)]/[3A: 7jl+ 73exp (A£/E7) j](Nm, monoradical amount), and by counting the
exact spin amount of the signal with a reference TANOL, both A* b and AE were determined …

DNA metallization: principles, methods, structures, and applications

Z Chen, C Liu, F Cao, J Ren, X Qu - Chemical Society Reviews, 2018 - pubs.rsc.org
DNA metallization has witnessed tremendous growth and development, from the initial
simple synthesis aimed at manufacturing conductive metal nanowires to the current …

Current concepts in antisense drug design

JF Milligan, MD Matteucci, JC Martin - Journal of medicinal …, 1993 - ACS Publications
Antisense oligodeoxynucleotides (ODNs) have been proposed as a major class of new
pharmaceuticals. In general, antisense refers to the use of small, synthetic oligonucleotides …

The synthesis of modified oligonucleotides by the phosphoramidite approach and their applications

SL Beaucage, RP Iyer - Tetrahedron, 1993 - Elsevier
The synthesis of modified oligonucleotides by the phosphoramidite approach and their
applications - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals & Books …

The use of phosphate bioisosteres in medicinal chemistry and chemical biology

TS Elliott, A Slowey, Y Ye, SJ Conway - MedChemComm, 2012 - pubs.rsc.org
Phosphate and pyrophosphate groups play a central role in cellular signalling and
consequently are of great interest to both medicinal chemists and chemical biologists …

Synthesis of DNA/RNA and their analogs via phosphoramidite and H-phosphonate chemistries

S Roy, M Caruthers - Molecules, 2013 - mdpi.com
The chemical synthesis of DNA and RNA is universally carried out using nucleoside
phosphoramidites or H-phosphonates as synthons. This review focuses on the phosphorus …

Modified internucleoside linkages for nuclease-resistant oligonucleotides

G Clavé, M Reverte, JJ Vasseur, M Smietana - RSC Chemical Biology, 2021 - pubs.rsc.org
In the past few years, several drugs derived from nucleic acids have been approved for
commercialization and many more are in clinical trials. The sensitivity of these molecules to …

2'-O-acetamido modified monomers and oligomers

M Manoharan, AM Kawasaki, PD Cook… - US Patent …, 2000 - Google Patents
Nucleosidic monomers and oligomeric compounds prepared therefrom are provided. Also
provided is a novel method of deprotection of oligomeric compounds. Oligomeric com …