A retrospective analysis of P. falciparum drug resistance markers detects an early (2016/17) high prevalence of the k13 C469Y mutation in asymptomatic infections in …
The emergence of drug-resistant Plasmodium falciparum parasites in sub-Saharan Africa
will substantially challenge malaria control. Here, we evaluated the frequency of common …
will substantially challenge malaria control. Here, we evaluated the frequency of common …
Seasonal malaria chemoprevention in a context of high presumed sulfadoxine-pyrimethamine resistance: malaria morbidity and molecular drug resistance profiles in …
I Molina-De la Fuente, MJ Sagrado Benito, E Lasry… - Malaria Journal, 2023 - Springer
Background Seasonal malaria chemoprevention (SMC) using sulfadoxine-pyrimethamine
plus amodiaquine (SP-AQ), is a community-based malaria preventive strategy commonly …
plus amodiaquine (SP-AQ), is a community-based malaria preventive strategy commonly …
Molecular surveillance of Kelch 13 polymorphisms in Plasmodium falciparum isolates from Kenya and Ethiopia
Background Timely molecular surveillance of Plasmodium falciparum kelch 13 (k13) gene
mutations is essential for monitoring the emergence and stemming the spread of artemisinin …
mutations is essential for monitoring the emergence and stemming the spread of artemisinin …
Imported malaria into Australia: surveillance insights and opportunities
Background Malaria continues to pose a significant burden in endemic countries, many of
which lack access to molecular surveillance. Insights from malaria cases in travellers …
which lack access to molecular surveillance. Insights from malaria cases in travellers …
Detection of low frequency artemisinin resistance mutations, C469Y, P553L and A675V, and fixed antifolate resistance mutations in asymptomatic primary school …
V Osoti, K Wamae, L Ndwiga, PM Gichuki… - BMC Infectious …, 2025 - Springer
Background To understand the emergence and spread of drug-resistant parasites in malaria-
endemic areas, accurate assessment and monitoring of antimalarial drug resistance …
endemic areas, accurate assessment and monitoring of antimalarial drug resistance …
ONT sequencing identifies a high prevalence of crt sensitive, triple mutant dhfr and single mutant dhps parasites within an ANC population in Nigeria
Background Malaria in pregnancy is a major public health issue, particularly among
vulnerable populations in malaria-endemic sub-Saharan African countries. To mitigate its …
vulnerable populations in malaria-endemic sub-Saharan African countries. To mitigate its …
Low frequency of Plasmodium falciparum hrp2/3 deletions from symptomatic infections at a primary healthcare facility in Kilifi, Kenya
D Okanda, L Ndwiga, V Osoti, N Achieng… - Frontiers in …, 2023 - frontiersin.org
There is a growing concern for malaria control in the Horn of Africa region due to the spread
and rise in the frequency of Plasmodium falciparum Histidine-rich Protein (hrp) 2 and 3 …
and rise in the frequency of Plasmodium falciparum Histidine-rich Protein (hrp) 2 and 3 …
Detection of Low-frequency Artemisinin resistance mutations C469Y, P553L and A675V in asymptomatic primary school children in Kenya
Background: To understand the emergence and spread of drug-resistant parasites in
malaria-endemic areas, accurate assessment and monitoring of antimalarial drug resistance …
malaria-endemic areas, accurate assessment and monitoring of antimalarial drug resistance …
Analytic optimization of Plasmodium falciparum marker gene haplotype recovery from amplicon deep sequencing of complex mixtures
Molecular epidemiologic studies of malaria parasites and other pathogens commonly
employ amplicon deep sequencing (AmpSeq) of marker genes derived from dried blood …
employ amplicon deep sequencing (AmpSeq) of marker genes derived from dried blood …
Molecular surveillance of artemisinin combination therapy resistance markers in Kelch13 gene of plasmodium falciparum isolates collected from Yobe State Nigeria
Background: Despite the discovery of artemisinin and artemisinin combination therapies
(ACTs), resistance emerged due to single-nucleotide polymorphisms (SNPs) at the Kelch13 …
(ACTs), resistance emerged due to single-nucleotide polymorphisms (SNPs) at the Kelch13 …