Piperidine derivatives: recent advances in synthesis and pharmacological applications

NA Frolov, AN Vereshchagin - International Journal of Molecular Sciences, 2023 - mdpi.com
Piperidines are among the most important synthetic fragments for designing drugs and play
a significant role in the pharmaceutical industry. Their derivatives are present in more than …

Bioactive natural compounds and antioxidant activity of essential oils from spice plants: New findings and potential applications

L Diniz do Nascimento, AA Barbosa de Moraes… - Biomolecules, 2020 - mdpi.com
Spice plants have a great influence on world history. For centuries, different civilizations
have used them to condiment the foods of kings and nobles and applied them as embalming …

Molecular and pharmacological aspects of piperine as a potential molecule for disease prevention and management: evidence from clinical trials

AK Tripathi, AK Ray, SK Mishra - Beni-Suef university journal of basic and …, 2022 - Springer
Background Piperine is a type of amide alkaloid that exhibits pleiotropic properties like
antioxidant, anticancer, anti-inflammatory, antihypertensive, hepatoprotective …

[HTML][HTML] Protective effects of medicinal plant-based foods against diabetes: a review on pharmacology, phytochemistry, and molecular mechanisms

P Ansari, JF Samia, JT Khan, MR Rafi, MS Rahman… - Nutrients, 2023 - mdpi.com
Diabetes mellitus (DM) comprises a range of metabolic disorders characterized by high
blood glucose levels caused by defects in insulin release, insulin action, or both. DM is a …

Experimental investigations on active solar dryers integrated with thermal storage for drying of black pepper

DVN Lakshmi, P Muthukumar, PK Nayak - Renewable Energy, 2021 - Elsevier
This study focusses on the experimental analyses of two active horizontal solar dryers viz.,
mixed mode (Case-I) and indirect solar dryer (Case-II) integrated with latent heat storage …

Binding mechanism and antioxidant activity of piperine to hemoglobin

X Hu, D Wu, L Tang, J Zhang, Z Zeng, F Geng, H Li - Food Chemistry, 2022 - Elsevier
Piperine (PIP) is the most active main component in pepper. The interaction of small
molecules with biomolecules leads to structural and functional changes. In this study, the …

Driving forces and large scale affinity calculations for piperine/γ-cyclodxetrin complexes: Mechanistic insights from umbrella sampling simulation and DFT calculations

P Kumar, R Purohit - Carbohydrate Polymers, 2024 - Elsevier
Piperine (PiP), a bioactive molecule, exhibits numerous health benefits and is frequently
employed as a co-delivery agent with various phytomedicines (eg, curcumin) to enhance …

Green synthesis of Piper nigrum copper-based nanoparticles: in silico study and ADMET analysis to assess their antioxidant, antibacterial, and cytotoxic effects

M Kiranmayee, N Rajesh, M Vidya Vani… - Frontiers in …, 2023 - frontiersin.org
Nanobiotechnology is a popular branch of science that is gaining interest among scientists
and researchers as it allows for the green manufacturing of nanoparticles by employing …

Thymoquinone, piperine, and sorafenib combinations attenuate liver and breast cancers progression: epigenetic and molecular docking approaches

AA El-Shehawy, A Elmetwalli, AH El-Far… - … Medicine and Therapies, 2023 - Springer
Background Traditional herbal medicine has been used for centuries to cure many
pathological disorders, including cancer. Thymoquinone (TQ) and piperine (PIP) are major …

Gut metabolites predict Clostridioides difficile recurrence

JJ Dawkins, JR Allegretti, TE Gibson, E McClure… - Microbiome, 2022 - Springer
Background Clostridioides difficile infection (CDI) is the most common hospital acquired
infection in the USA, with recurrence rates> 15%. Although primary CDI has been …