Retinopathy of prematurity (ROP) is a disease that can cause blindness in very low
birthweight infants. The incidence of ROP is closely correlated with the weight and the …

The “fetal origin of adult disease Hypothesis” originally described by Barker et al. identified
the relationship between impaired in utero growth and adult cardiovascular disease risk and …

It is now recognized that the quality of the fetal environment during early development is
important in programming cardiovascular health and disease in later life. Fetal hypoxia is …

Purpose.: Oxygen-induced retinopathy (OIR) is a model for human retinopathy of prematurity
(ROP). In OIR mice, this study determined whether blockade of β-adrenergic receptors (β …

Retinal neovascular pathologies, such as diabetic retinopathy, retinopathy of prematurity
(ROP) and age-related macular degeneration, may be treated with intravitreal injections of …

The benign public perception of myopia (nearsightedness) as a visual inconvenience masks
the severity of its sight-threatening consequences. Myopia is a significant risk factor for …

β-adrenoreceptors (ARs) are members of the superfamily of G-protein-coupled receptors
(GPCRs), and are activated by catecholamines, such as epinephrine and norepinephrine …

Background Despite new therapeutic approaches have improved the prognosis of newborns
with retinopathy of prematurity (ROP), an unfavourable structural and functional outcome still …

Cardiac phenotypic plasticity, the remodelling of heart structure and function, is a response
to any sustained (or repeated) stimulus or stressor that results in a change in heart …

Background: Impaired beta-adrenergic receptor (β1 and β2AR) function following hypoxia
underlies ischemic heart failure/stroke. Activation of PI3Kγ (phosphoinositide 3-kinase γ) by …