Acids and bases are ubiquitous in chemistry. Our understanding of them, however, is
dominated by their behaviour in water. Transfer to non-aqueous solvents leads to profound …

The apparent acid dissociation constants (psKa) of two water-insoluble drugs, ibuprofen and
quinine, were determined pH-metrically in acetonitrile–water, dimethylformamide–water …

An accurate estimation of pKa values in methanol–water binary mixtures is very important for
several separation techniques such as liquid chromatography and capillary electrophoresis …

Several properties of methanol− water mixtures (molar volume, molar refractivity, Debye−
Hückel parameters, pH scale, HPLC-useful pH range, dissociation constants of acids) are …

The pH calibration procedures that lead to the different pH scales in acetonitrile− water
mixtures used as mobile phases in reversed-phase liquid chromatography are discussed …

The dissociation constants in several acetonitrile-water mixtures of the carboxylic acid
groups of 19 substances, included into four different sets (diuretics, quinolones, buffers and …

The retention of ionogenic bases in liquid chromatography is strongly dependent upon the
pH of the mobile phase. Chromatographic behavior of a series of substituted aniline and …

A critical compilation of the literature pK data for acetonitrile–water is presented and
equations and parameters that allow estimation of the pK of these compounds for any …

The addition of acetonitrile to aqueous buffers to prepare RP HPLC mobile phases changes
the buffer properties (pH and buffer capacity). This variation is studied for acetate …

This paper examines the effect of solute ionisation on the retention behaviour of a series of
quinolones and evaluates their pKa values using chromatographic data in acetonitrile–water …