RNA-guided systems, which use complementarity between a guide RNA and target nucleic
acid sequences for recognition of genetic elements, have a central role in biological …

Perilipins are abundant lipid droplet (LD) proteins present in all metazoans and also in
Amoebozoa and fungi. Humans express five perilipins, which share a similar domain …

Insertions and deletions constitute the second most important source of natural genomic
variation. Insertions and deletions make up to 25% of genomic variants in humans and are …

Technologically critical rare-earth elements are notoriously difficult to separate, owing to
their subtle differences in ionic radius and coordination number,–. The natural lanthanide …

Effective pandemic preparedness relies on anticipating viral mutations that are able to
evade host immune responses to facilitate vaccine and therapeutic design. However, current …

CRISPR systems are widespread in the prokaryotic world, providing adaptive immunity
against mobile genetic elements,. Type III CRISPR systems, with the signature gene cas10 …

It is commonly held that there is a fundamental relationship between genome size and error
rate, manifest as a notional “error threshold” that sets an upper limit on genome sizes. The …

Viral glycoproteins drive membrane fusion in enveloped viruses and determine host range,
tissue tropism and pathogenesis. Despite their importance, there is a fragmentary …

Pangenomes are collections of annotated genome sequences of multiple individuals of a
species. The structural variants uncovered by these datasets are a major asset to genetic …

Deciphering the immune organization of eukaryotes is important for human health and for
understanding ecosystems. The recent discovery of antiphage systems revealed that various …