Epithelial tight junctions define the paracellular permeability of the intestinal barrier.
Molecules can cross the tight junctions via two distinct size-selective and charge-selective …

Background and Aim: Irritable bowel syndrome (IBS) is a complex and heterogeneous
disorder. Sensory, motor and barrier dysfunctions are the key physiological endophenotypes …

The broad role of stress in the brain-gut axis is widely acknowledged, with implications for
multiple prevalent health conditions that are characterized by chronic gastrointestinal …

Functional gastrointestinal disorders—recently renamed into disorders of gut–brain
interaction—such as irritable bowel syndrome and functional dyspepsia are highly prevalent …

Objective To improve the pathophysiological understanding of irritable bowel syndrome
(IBS) by exploring the gut-brain axis. Background Disorders of gut-brain interaction (DGBIs) …

Chronic primary pain (CPP) is a group of diseases with long‐term pain and functional
disorders but without structural or specific tissue pathologies. CPP is becoming a serious …

Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder characterized
by recurring abdominal pain and altered bowel habits without detectable organic causes …

Most gastrointestinal diseases and disorders (GIDD) are associated with depression,
anxiety, and cognitive dysfunction. This suggests that shared features of GIDD, particularly …

Stress is broadly defined as the non-specific biological response to changes in homeostatic
demands and is mediated by the evolutionarily conserved neuroendocrine networks of the …

Background Major depressive disorder (MDD) is the leading cause of disability worldwide.
Of individuals with MDD, 30% to 50% are unresponsive to common antidepressants …