An increasing number of studies show how changes in intracellular metabolic pathways
alter tumor and immune cell function. However, little information about metabolic changes in …

Abnormal choline metabolism is emerging as a metabolic hallmark that is associated with
oncogenesis and tumour progression. Following transformation, the modulation of enzymes …

The glycerophospholipids phosphatidylcholine (PC) and phosphatidylethanolamine (PE)
account for greater than 50% of the total phospholipid species in eukaryotic membranes and …

The endoplasmic reticulum (ER) is an interconnected network of tubular and planar
membranes that supports the synthesis and export of proteins, carbohydrates and lipids …

Swelling and the progressive destruction of articular cartilage are major characteristics of
rheumatoid arthritis (RA), a systemic autoimmune disease that directly affects the synovial …

The basic helix-loop-helix-PAS transcription factor (CLOCK, Circadian locomotor output
cycles protein kaput) was discovered in 1994 as a circadian clock. Soon after its discovery …

Metabolomics enables the profiling of large numbers of small molecules in cells, tissues and
biological fluids. These molecules, which include amino acids, carbohydrates, lipids …

CTP: phosphocholine cytidylyltransferase (CCT) catalyzes a rate-limiting and regulated step
in the CDP-choline pathway for the synthesis of phosphatidylcholine (PC) and PC-derived …

5-Fluorouracil (5-FU) is the most used chemotherapeutic agent in colorectal cancer.
However, resistance to this drug is relatively frequent, and new strategies to overcome it are …

The majority of pharmaceuticals and other organic compounds incorporating radiotracers
that are considered foreign to the body undergo metabolic changes in vivo. Metabolic …