Advances in the carbonic anhydrase (CA, EC 4.2. 1.1) research over the last three decades
are presented, with an emphasis on the deciphering of the activation mechanism, the …

While cancer is commonly described as “a disease of the genes,” it is also associated with
massive metabolic reprogramming that is now accepted as a disease “Hallmark.” This …

Carbonic anhydrases (CAs, EC 4.2. 1.1) are ubiquitous metallo-enzymes, present
throughout most living organisms and encoded by five evolutionarily unrelated gene …

Over the past decades, the bulk of chemists' interests have been on heterocyclic compounds
and their various derivatives as well as their applications in the pharmaceutical and …

Human carbonic anhydrase (CA) IX is a tumor‐associated protein, since it is scarcely
present in normal tissues, but highly overexpressed in a large number of solid tumors, where …

Carbonic anhydrases (CAs), a group of ubiquitously expressed metalloenzymes, are
involved in numerous physiological and pathological processes, including …

The 1, 3, 4‐thiadiazole nucleus is one of the most important and well‐known heterocyclic
nuclei, which is a common and integral feature of a variety of natural products and medicinal …

Many compounds containing a five‐membered heterocyclic ring display exceptional
chemical properties and versatile biological activities. In this Minireview, thiadiazoles are …

The Neurovascular Unit (NVU) is an important multicellular structure of the central nervous
system (CNS), which participates in the regulation of cerebral blood flow (CBF), delivery of …

E7070 [N-(3-chloro-7-indolyl)-1, 4-benzenedisulfonamide] is an anticancer drug candidate
under clinical development for the treatment of several types of cancers. We prove here that …