Unlike most other organelles found in multiple copies, the endoplasmic reticulum (ER) is a
unique singular organelle within eukaryotic cells. Despite its continuous membrane …

Cell homeostasis and function rely on well-orchestrated communication between different
organelles. This communication is ensured by signaling pathways and membrane contact …

Phosphoinositides are amphipathic lipid molecules derived from phosphatidylinositol that
represent low abundance components of biological membranes. Rather than serving as …

Phosphoinositide 3-kinases regulate many cellular functions, including migration, growth,
proliferation, and cell survival. Early studies equated the inhibition of Class I PI3Ks with loss …

Migrasomes, newly identified organelles, play crucial roles in intercellular communication,
contributing to organ development and angiogenesis. These vesicles, forming on retraction …

Late endosomes/lysosomes (LELs) are crucial for numerous physiological processes and
their dysfunction is linked to many diseases. Proteomic analyses have identified hundreds of …

Tuberous sclerosis complex (TSC) is targeted to the lysosomal membrane, where it
hydrolyzes RAS homolog–mTORC1 binding (RHEB) from its GTP-bound to GDP-bound …

ARL5 is a member of the ARF family of small GTPases that is recruited to the trans-Golgi
network (TGN) by another ARF-family member, ARFRP1, in complex with the …

PRL1 and PRL3, members of the protein tyrosine phosphatase family, have been
associated with cancer metastasis and poor prognosis. Despite extensive research on their …

Background Eukaryotic cells are highly compartmentalized by a variety of organelles that
carry out specific cellular processes. The position of these organelles within the cell is …