[HTML][HTML] Viral oncology: molecular biology and pathogenesis

UN Mui, CT Haley, SK Tyring - Journal of clinical medicine, 2017 - mdpi.com
Oncoviruses are implicated in approximately 12% of all human cancers. A large number of
the world's population harbors at least one of these oncoviruses, but only a small proportion …

HTLV-1-associated myelopathy/tropical spastic paraparesis

CRM Bangham, A Araujo, Y Yamano… - Nature reviews Disease …, 2015 - nature.com
Human T-lymphotropic virus 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis
(HAM/TSP) is a progressive disease of the CNS that causes weakness or paralysis of the …

HTLV-1 infection: An emerging risk. Pathogenesis, epidemiology, diagnosis and associated diseases

E Eusebio-Ponce, E Anguita… - Revista Española …, 2019 - pmc.ncbi.nlm.nih.gov
ABSTRACT The Human T-Lymphotropic Virus type 1 (HTLV-1) affects up to 10 million
people worldwide. It is directly associated to one of the most aggressive T cell malignancies …

The host genomic environment of the provirus determines the abundance of HTLV-1–infected T-cell clones

NA Gillet, N Malani, A Melamed… - Blood, The Journal …, 2011 - ashpublications.org
Human T-lymphotropic virus type 1 (HTLV-1) persists by driving clonal proliferation of
infected T lymphocytes. A high proviral load predisposes to HTLV-1–associated diseases …

Human T cell leukemia virus type 1: persistence and pathogenesis

CRM Bangham - Annual review of immunology, 2018 - annualreviews.org
Human T cell leukemia virus type 1 (HTLV-1), also known as human T lymphotropic virus
type 1, was the first exogenous human retrovirus discovered. Unlike the distantly related …

40 years of the human T-cell leukemia virus: past, present, and future

Y Tagaya, M Matsuoka, R Gallo - F1000Research, 2019 - pmc.ncbi.nlm.nih.gov
It has been nearly 40 years since human T-cell leukemia virus-1 (HTLV-1), the first
oncogenic retrovirus in humans and the first demonstrable cause of cancer by an infectious …

Multifaceted functions and roles of HBZ in HTLV-1 pathogenesis

G Ma, J Yasunaga, M Matsuoka - Retrovirology, 2016 - Springer
Human T cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus responsible for the
development of adult T-cell leukemia (ATL). Although HTLV-1 harbors an oncogene, tax …

Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding

PE Chappell, EK Meziane, M Harrison, Ł Magiera… - elife, 2015 - elifesciences.org
Highly polymorphic major histocompatibility complex (MHC) molecules are at the heart of
adaptive immune responses, playing crucial roles in many kinds of disease and in …

Inflammatory manifestations of HTLV-1 and their therapeutic options

F Martin, GP Taylor, S Jacobson - Expert review of clinical …, 2014 - Taylor & Francis
Human T lymphotropic virus type 1 (HTLV-1) is one of the most intriguing retroviruses
infecting humans. Most commonly, infection remains undetected, since it does not cause …

Tropical spastic paraparesis and HTLV-1 associated myelopathy: clinical, epidemiological, virological and therapeutic aspects

A Gessain, R Mahieux - Revue neurologique, 2012 - Elsevier
In 1980, HumanT cell leukemia/lymphoma virus type 1 (HTLV-1) was the first oncogenic
human retrovirus to be discovered. HTLV-1 belongs to the Retroviridae family, the …