Structural identifiability analysis of epidemic models based on differential equations: a tutorial-based primer

G Chowell, S Dahal, YR Liyanage, A Tariq… - Journal of Mathematical …, 2023 - Springer
The successful application of epidemic models hinges on our ability to estimate model
parameters from limited observations reliably. An often-overlooked step before estimating …

A novel methodology for epidemic risk assessment of COVID-19 outbreak

A Pluchino, AE Biondo, N Giuffrida, G Inturri… - Scientific Reports, 2021 - nature.com
We propose a novel data-driven framework for assessing the a-priori epidemic risk of a
geographical area and for identifying high-risk areas within a country. Our risk index is …

Reconstructing higher-order interactions in coupled dynamical systems

F Malizia, A Corso, LV Gambuzza, G Russo… - Nature …, 2024 - nature.com
Higher-order interactions play a key role for the operation and function of a complex system.
However, how to identify them is still an open problem. Here, we propose a method to fully …

How robust are estimates of key parameters in standard viral dynamic models?

C Zitzmann, R Ke, RM Ribeiro… - PLOS Computational …, 2024 - journals.plos.org
Mathematical models of viral infection have been developed, fitted to data, and provide
insight into disease pathogenesis for multiple agents that cause chronic infection, including …

An integrated framework for building trustworthy data-driven epidemiological models: Application to the COVID-19 outbreak in New York City

S Zhang, J Ponce, Z Zhang, G Lin… - PLoS computational …, 2021 - journals.plos.org
Epidemiological models can provide the dynamic evolution of a pandemic but they are
based on many assumptions and parameters that have to be adjusted over the time the …

[HTML][HTML] A modified PINN Approach for Identifiable Compartmental models in Epidemiology with Application to COVID-19

H Hu, CM Kennedy, PG Kevrekidis, HK Zhang - Viruses, 2022 - mdpi.com
Many approaches using compartmental models have been used to study the COVID-19
pandemic, with machine learning methods applied to these models having particularly …

Temporal dynamics and interplay of transmission rate, vaccination, and mutation in epidemic modeling: A poisson point process approach

NM Shahtori, SF Atashzar - IEEE Transactions on Network …, 2024 - ieeexplore.ieee.org
One of the significant challenges when a new virus circulates in a host population is to
detect the outbreak as it arises in a timely fashion and implement the appropriate preventive …

System identifiability in a time-evolving agent-based model

TT Robin, J Cascante-Vega, J Shaman, S Pei - Plos one, 2024 - journals.plos.org
Mathematical models are a valuable tool for studying and predicting the spread of infectious
agents. The accuracy of model simulations and predictions invariably depends on the …

On the origins and rarity of locally but not globally identifiable parameters in biological modeling

XR Barreiro, AF Villaverde - IEEE Access, 2023 - ieeexplore.ieee.org
Structural identifiability determines the possibility of estimating the parameters of a model by
observing its output in an ideal experiment. If a parameter is structurally locally identifiable …

Why controlling the asymptomatic infection is important: A modelling study with stability and sensitivity analysis

J Pan, Z Chen, Y He, T Liu, X Cheng, J **ao… - Fractal and …, 2022 - mdpi.com
The large proportion of asymptomatic patients is the major cause leading to the COVID-19
pandemic which is still a significant threat to the whole world. A six-dimensional ODE system …