Tumour budding in solid cancers

A Lugli, I Zlobec, MD Berger, R Kirsch… - Nature Reviews Clinical …, 2021‏ - nature.com
Tumour budding is an emerging prognostic biomarker in colorectal cancer (CRC) and other
solid cancers. Tumour buds are usually defined as isolated single cancer cells or clusters of …

Systems biology of cancer metastasis

Y Suhail, MP Cain, K Vanaja, PA Kurywchak… - Cell systems, 2019‏ - cell.com
Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series
of concurrent, partially overlap** processes, as successfully metastasizing cells assume …

Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer

JL Galeano Niño, H Wu, KD LaCourse… - Nature, 2022‏ - nature.com
The tumour-associated microbiota is an intrinsic component of the tumour microenvironment
across human cancer types,. Intratumoral host–microbiota studies have so far largely relied …

A review of cell-based computational modeling in cancer biology

J Metzcar, Y Wang, R Heiland… - JCO clinical cancer …, 2019‏ - ascopubs.org
Cancer biology involves complex, dynamic interactions between cancer cells and their
tissue microenvironments. Single-cell effects are critical drivers of clinical progression …

Emerging role of tumor cell plasticity in modifying therapeutic response

S Qin, J Jiang, Y Lu, EC Nice, C Huang… - Signal transduction and …, 2020‏ - nature.com
Resistance to cancer therapy is a major barrier to cancer management. Conventional views
have proposed that acquisition of resistance may result from genetic mutations. However …

The mathematics of cancer: integrating quantitative models

PM Altrock, LL Liu, F Michor - Nature Reviews Cancer, 2015‏ - nature.com
Mathematical modelling approaches have become increasingly abundant in cancer
research. The complexity of cancer is well suited to quantitative approaches as it provides …

Glioblastoma microenvironment and invasiveness: new insights and therapeutic targets

JI Erices, C Bizama, I Niechi, D Uribe… - International Journal of …, 2023‏ - mdpi.com
Glioblastoma (GBM) is the most common and malignant primary brain cancer in adults.
Without treatment the mean patient survival is approximately 6 months, which can be …

Tumour heterogeneity and the evolutionary trade-offs of cancer

J Hausser, U Alon - Nature Reviews Cancer, 2020‏ - nature.com
Tumours vary in gene expression programmes and genetic alterations. Understanding this
diversity and its biological meaning requires a theoretical framework, which could in turn …

Tumor budding: the name is EMT. Partial EMT.

AD Grigore, MK Jolly, D Jia, MC Farach-Carson… - Journal of clinical …, 2016‏ - mdpi.com
Tumor budding is a histological phenomenon encountered in various cancers, whereby
individual malignant cells and/or small clusters of malignant cells are seen in the tumor …

The biology and mathematical modelling of glioma invasion: a review

JCL Alfonso, K Talkenberger… - Journal of the …, 2017‏ - royalsocietypublishing.org
Adult gliomas are aggressive brain tumours associated with low patient survival rates and
limited life expectancy. The most important hallmark of this type of tumour is its invasive …