Background Cancer is the most prevalent cause of death globally, and radiotherapy is
considered the standard of care for most solid tumors, including lung, breast, esophageal …

A variety of targeted anticancer agents have been successfully introduced into clinical
practice, largely reflecting their ability to inhibit specific molecular alterations that are …

Therapeutic applications of nuclease-based genome editing would benefit from improved
methods for transgene integration via homology-directed repair (HDR). To improve HDR …

Genome instability has been identified as one of the enabling hallmarks in cancer. DNA
damage response (DDR) network is responsible for maintenance of genome integrity in …

DDR (DNA damage response) defects in cells drive tumor formation by promoting DNA
mutations, which also provides cancer-specific vulnerabilities that can be targeted by …

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a member of the
phosphatidylinositol 3-kinase related kinase family, which can phosphorylate more than 700 …

Simple Summary A major theory of cancer development is that cancer originates from a
specialised type of tumour cell called the cancer stem cell (CSC). Although CSCs comprise …

DNA double-strand breaks (DSB) are repaired by multiple distinct pathways, with outcomes
ranging from error-free repair to mutagenesis and genomic loss. DSB-repair pathway cross …

Protein phosphorylation is an important post‐transcriptional modification involving an
extremely wide range of intracellular signaling transduction pathways, making it an …

DNA damage response (DDR) is critical to ensure genome stability, and defects in this
signaling pathway are highly associated with carcinogenesis and tumor progression …