T cell exhaustion is a state of T cell dysfunction that arises during many chronic infections
and cancer. It is defined by poor effector function, sustained expression of inhibitory …

Since the identification of the hepatitis C virus (HCV) 20 years ago, much progress has been
made in our understanding of its life cycle and interaction with the host immune system …

The clinical course of autoimmune and infectious disease varies greatly, even between
individuals with the same condition. An understanding of the molecular basis for this …

A protective vaccine against hepatitis C virus (HCV) remains an unmet clinical need. HCV
infects millions of people worldwide and is a leading cause of liver cirrhosis and …

В монографии приведены сведения по роли цитокинов в регуляции физиологических
процессов, защитных реакций организма и в патогенезе иммунопатологических …

Hepatitis C virus (HCV) infection is the major risk factor for liver cirrhosis and hepatocellular
carcinoma (HCC). The mechanisms of HCC initiation, growth, and metastasis appear to be …

Five human hepatitis viruses cause most of the acute and chronic liver disease worldwide.
Over the past 25 years, hepatitis C virus (HCV) in particular has received much interest …

Hepatitis C virus (HCV)-specific CD8 cell exhaustion may represent a mechanism of HCV
persistence. The inhibitory receptor PD-1 has been reported to be up-regulated in …

Background & Aims Chronic hepatitis C virus (HCV) infection is characterised by a failure of
virus-specific CD8+ T cells that is mainly caused by viral escape and T cell exhaustion …

The impact of virus dose on the outcome of infection is poorly understood. In this study we
show that, for hepatitis B virus (HBV), the size of the inoculum contributes to the kinetics of …