Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of
approaches that assess the binding mode and nature of the interactions between G4 …

G-quadruplexes (G4s) are non-canonical secondary nucleic acid structures. Sequences with
the potential to form G4s are abundant in regulatory regions of the genome including …

Ligand/protein molecular recognition involves a dynamic process, whereby both partners
require a degree of structural plasticity to regulate the binding/unbinding event. Here, we …

Targeted therapy is highly desirable, as it allows for selective cytotoxicity on diseased cells
without off-target side effects. Nucleolin is a remarkable target for cancer therapy given its …

AS1411 aptamer can function as a recognition probe to detect the cell surface nucleolin
overexpressed in cancer cells, however, little is known about their binding process. This …

In recent years, G-quadruplexes (G4s), types of noncanonical four-stranded nucleic acid
structures, have been identified in many viruses that threaten human health, such as HIV …

Targeted cancer therapy has become one of the most important medical methods because
of the spreading and metastatic nature of cancer. Based on the introduction of AS1411 and …

Understanding the mechanisms of carcinogenesis is essential to combat cancer. The search
for alternative targets for anticancer therapy has gained interest, particularly when focused …

Nucleolin (NCL) is a multifunctional nuclear protein that plays significant roles in regulating
physiological activities of the cells. However, it remains a challenge to monitor the dynamic …

Photolithography combined with surface nucleated protein self‐assembly of azido‐modified
spider silk proteins is used to create an arbitrarily shaped, inherently cell repellent …