Tendinopathy

NL Millar, KG Silbernagel, K Thorborg… - Nature reviews Disease …, 2021 - nature.com
Tendinopathy describes a complex multifaceted pathology of the tendon, characterized by
pain, decline in function and reduced exercise tolerance. The most common overuse …

[HTML][HTML] Tendon injury and repair–A perspective on the basic mechanisms of tendon disease and future clinical therapy

JG Snedeker, J Foolen - Acta biomaterialia, 2017 - Elsevier
Tendon is an intricately organized connective tissue that efficiently transfers muscle force to
the bony skeleton. Its structure, function, and physiology reflect the extreme, repetitive …

The cellular basis of fibrotic tendon healing: challenges and opportunities

AEC Nichols, KT Best, AE Loiselle - Translational Research, 2019 - Elsevier
Tendon injuries are common and can dramatically impair patient mobility and productivity,
resulting in a significant socioeconomic burden and reduced quality of life. Because the …

A clinical, biological, and biomaterials perspective into tendon injuries and regeneration

G Walden, X Liao, S Donell, MJ Raxworthy… - … Engineering Part B …, 2017 - liebertpub.com
Tendon injury is common and debilitating, and it is associated with long-term pain and
ineffective healing. It is estimated to afflict 25% of the adult population and is often a career …

Structural mechanisms in soft fibrous tissues: a review

M Sharabi - Frontiers in Materials, 2022 - frontiersin.org
Through years of evolution, biological soft fibrous tissues have developed remarkable
functional properties, unique hierarchical architectures, and-most notably, an unparalleled …

Elastin is localised to the interfascicular matrix of energy storing tendons and becomes increasingly disorganised with ageing

MSC Godinho, CT Thorpe, SE Greenwald… - Scientific reports, 2017 - nature.com
Tendon is composed of fascicles bound together by the interfascicular matrix (IFM). Energy
storing tendons are more elastic and extensible than positional tendons; behaviour provided …

Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition

CT Thorpe, MJ Peffers, D Simpson, E Halliwell… - Scientific reports, 2016 - nature.com
Tendon is a simple aligned fibre composite, consisting of collagen-rich fascicles surrounded
by a softer interfascicular matrix (IFM). The composition and interactions between these …

Biological connective tissues exhibit viscoelastic and poroelastic behavior at different frequency regimes: Application to tendon and skin biophysics

R Oftadeh, BK Connizzo, HT Nia, C Ortiz… - Acta biomaterialia, 2018 - Elsevier
In this study, a poroviscoelastic finite element model (FEM) was developed and used in
conjunction with an AFM-based wide-bandwidth nanorheology system to predict the …

Female tendons are from Venus and male tendons are from Mars, but does it matter for tendon health?

G McMahon, J Cook - Sports medicine, 2024 - Springer
Tendons play fundamental roles in the execution of human movement and therefore
understanding tendon function, health and disease is important for everyday living and …

Plantarflexor strength and endurance deficits associated with mid-portion Achilles tendinopathy: the role of soleus

S O'Neill, S Barry, P Watson - Physical Therapy in Sport, 2019 - Elsevier
Objectives Determine how the strength and endurance of the plantar flexors are affected by
Achilles tendinopathy and whether one muscle is more affected than another. Design Case …