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[HTML][HTML] The hallmarks of cancer metabolism: Still emerging
Metabolism of cancer cells is geared toward biomass production and proliferation. Since the
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …
Microenvironment-driven metabolic adaptations guiding CD8+ T cell anti-tumor immunity
J Park, PC Hsueh, Z Li, PC Ho - Immunity, 2023 - cell.com
The metabolic stress occurring in the tumor microenvironment (TME) hampers T cell anti-
tumor immunity by disturbing T cell metabolic and epigenetic programs. Recent studies are …
tumor immunity by disturbing T cell metabolic and epigenetic programs. Recent studies are …
CD8+ T cell metabolism in infection and cancer
Cytotoxic CD8+ T cells play a key role in the elimination of intracellular infections and
malignant cells and can provide long-term protective immunity. In the response to infection …
malignant cells and can provide long-term protective immunity. In the response to infection …
Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment
J Cheng, J Yan, Y Liu, J Shi, H Wang, H Zhou, Y Zhou… - Cell metabolism, 2023 - cell.com
Metabolic alterations in the microenvironment significantly modulate tumor
immunosensitivity, but the underlying mechanisms remain obscure. Here, we report that …
immunosensitivity, but the underlying mechanisms remain obscure. Here, we report that …
Amino assets: how amino acids support immunity
Amino acids are fundamental building blocks supporting life. Their role in protein synthesis
is well defined, but they contribute to a host of other intracellular metabolic pathways …
is well defined, but they contribute to a host of other intracellular metabolic pathways …
Carbon source availability drives nutrient utilization in CD8+ T cells
How environmental nutrient availability impacts T cell metabolism and function remains
poorly understood. Here, we report that the presence of physiologic carbon sources (PCSs) …
poorly understood. Here, we report that the presence of physiologic carbon sources (PCSs) …
Metabolism of amino acids in cancer
Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The
uptake and metabolism of amino acids are aberrantly upregulated in many cancers that …
uptake and metabolism of amino acids are aberrantly upregulated in many cancers that …
Immunometabolic interplay in the tumor microenvironment
Immune cells' metabolism influences their differentiation and function. Given that a complex
interplay of environmental factors within the tumor microenvironment (TME) can have a …
interplay of environmental factors within the tumor microenvironment (TME) can have a …
Nutrients: Signal 4 in T cell immunity
T cells are integral in mediating adaptive immunity to infection, autoimmunity, and cancer.
Upon immune challenge, T cells exit from a quiescent state, followed by clonal expansion …
Upon immune challenge, T cells exit from a quiescent state, followed by clonal expansion …
Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer
Rapidly proliferating tumor and immune cells need metabolic programs that support energy
and biomass production. The amino acid glutamine is consumed by effector T cells and …
and biomass production. The amino acid glutamine is consumed by effector T cells and …