Clostridium difficile is a major cause of intestinal infection and diarrhoea in individuals
following antibiotic treatment. Recent studies have begun to elucidate the mechanisms that …

Clostridioides difficile is a Gram-positive, spore-forming, toxin-producing anaerobe, and an
important nosocomial pathogen. Due to the strictly anaerobic nature of the vegetative form …

The current classification of the phylum Firmicutes (new name, Bacillota) features eight
distinct classes, six of which include known spore-forming bacteria. In Bacillus subtilis …

Spore formation and germination are essential for the bacterial pathogen Clostridioides
difficile to transmit infection. Despite the importance of these developmental processes to the …

Endospore formation has been a rich field of research for more than a century, and has
benefited from the powerful genetic tools available in Bacillus subtilis. In this review, we …

As obligate anaerobes, clostridial pathogens depend on their metabolically dormant, oxygen-
tolerant spore form to transmit disease. However, the molecular mechanisms by which those …

Sporulation is a specialized developmental program employed by a diverse set of bacteria
which culminates in the formation of dormant cells displaying increased resilience to …

The Clostridium genus harbors compelling organisms for biotechnological production
processes; while acetogenic clostridia can fix C1-compounds to produce acetate and …

One of the biggest limitations in the study and engineering of anaerobic Clostridium
organisms is the lack of strong fluorescent reporters capable of strong and real-time …

Clostridium difficile is the major etiologic agent of antibiotic-associated intestinal disease.
Pathogenesis of C. difficile is mainly attributed to the production and secretion of toxins A …