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Metal–ligand interactions in drug design
The fast-growing body of experimental data on metalloenzymes and organometallic
compounds is fostering the exploitation of metal–ligand interactions for the design of new …
compounds is fostering the exploitation of metal–ligand interactions for the design of new …
Hybrid quantum mechanical/molecular mechanical methods for studying energy transduction in biomolecular machines
Hybrid quantum mechanical/molecular mechanical (QM/MM) methods have become
indispensable tools for the study of biomolecules. In this article, we briefly review the basic …
indispensable tools for the study of biomolecules. In this article, we briefly review the basic …
The Grignard reaction–unraveling a chemical puzzle
More than 100 years since its discovery, the mechanism of the Grignard reaction remains
unresolved. Ambiguities arise from the concomitant presence of multiple organomagnesium …
unresolved. Ambiguities arise from the concomitant presence of multiple organomagnesium …
Catalytic Mechanism of Non-Target DNA Cleavage in CRISPR-Cas9 Revealed by Ab Initio Molecular Dynamics
CRISPR-Cas9 is a cutting-edge genome editing technology, which uses the endonuclease
Cas9 to introduce mutations at desired sites of the genome. This revolutionary tool is …
Cas9 to introduce mutations at desired sites of the genome. This revolutionary tool is …
A synthetic genetic polymer with an uncharged backbone chemistry based on alkyl phosphonate nucleic acids
The physicochemical properties of nucleic acids are dominated by their highly charged
phosphodiester backbone chemistry. This polyelectrolyte structure decouples information …
phosphodiester backbone chemistry. This polyelectrolyte structure decouples information …
Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides
Phosphorothioates (PS) have proven their effectiveness in the area of therapeutic
oligonucleotides with applications spanning from cancer treatment to neurodegenerative …
oligonucleotides with applications spanning from cancer treatment to neurodegenerative …
RNA synthesis and cap** by non-segmented negative strand RNA viral polymerases: lessons from a prototypic virus
Non-segmented negative strand (NNS) RNA viruses belonging to the order
Mononegavirales are highly diversified eukaryotic viruses including significant human …
Mononegavirales are highly diversified eukaryotic viruses including significant human …
Viral RNA replication suppression of SARS-CoV-2: Atomistic insights into inhibition mechanisms of RdRp machinery by ddhCTP
The nonstructural protein 12, known as RNA-dependent RNA polymerase (RdRp), is
essential for both replication and repair of the viral genome. The RdRp of SARS-CoV-2 has …
essential for both replication and repair of the viral genome. The RdRp of SARS-CoV-2 has …
Engineering polymerases for applications in synthetic biology
DNA polymerases play a central role in biology by transferring genetic information from one
generation to the next during cell division. Harnessing the power of these enzymes in the …
generation to the next during cell division. Harnessing the power of these enzymes in the …
Machines on genes through the computational microscope
Macromolecular machines acting on genes are at the core of life's fundamental processes,
including DNA replication and repair, gene transcription and regulation, chromatin …
including DNA replication and repair, gene transcription and regulation, chromatin …